Mary L. (Nora) Disis
@DrNDisis
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Director, UW Medicine Cancer Vaccine Institute. Editor in Chief, JAMA Oncology. Research: vaccines for the prevention of cancer and cancer relapse.
University of Washington
Joined February 2015
CVI Director @DrNDisis, Exec Dir @kirandhillonphd & colleagues are at #SITC2022! Grad students & postdocs interested in an exciting career in cancer vaccines & tumor immunology, we want to meet you! Discovery, translation, and clinical trials under one roof. Email: kkd@uw.edu
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RT @UWCancerVaccine: We’re excited to share a new paper by CVI’s Dr. John Liao on a clinical trial for combination Pembrolizumab and low do….
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RT @science_seattle: 👨⚕️👩⚕️ Drs. Sasha Stanton (@sestant29), Nora Disis (@DrNDisis), and fellow @UWCancerVaccine researchers found that c….
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RT @uwmnewsroom: 5 immune response markers might predict #COVID19 patient outcomes & possibly become useful in candidate vaccine assessment….
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RT @JackWestMD: In the wake of #ADAURA trial, what will your practice be for molecular testing in patients with resected stage IB-IIIA NSCL….
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RT @0131Liu: Thanks for my nicest colleagues! I am the best, because all of you! @UWCancerVaccine.
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Laura is an amazing scientist!.
CVI’s Dr. Laura Riolobos is making a #vaccine for #liposarcoma, to help her friend & others with this rare #cancer. Read more: @UWMedicine #SarcomaAwareness #CureSarcoma #Sarcoma #Research
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Pembrolizumab After Locally Ablative Therapy for Oligometastatic Non–Small Cell Lung Cancer New at @JAMA Onc-ablation of oligometastatic NSCLC followed by immune checkpoint: OS at 12 mo-90%. Novel and promising application of immune checkpoint inhibition.
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Regulatory roles of IL-10–producing human follicular T cells
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I'm a fan of testing early. Immune therapy more be more effective with less bulky disease.
Fascinating. Test early or late in the disease course? Seems like later could pick up more candidates for IO.
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RT @guptaarjun90: Patient page on #CIPN (Chemo Induced Peripheral Neuropathy), in @JAMAOnc w/ @TimothyJBrownMD @ramsedhom .#QOL matters. Ca….
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Thank you UW CVI #ImmunoOnc19 @UWCancerVaccine.
Just a reminder that you can’t top @thenci ‘s @gulleyj1 for #immunotherapy on Twitter 😉. Thank you also @DrChoueiri @DrNDisis @asco @sitc @PGrivasMDPhD @xiaoweimd @CMAnnunziata @phase1oncomd et al for a great #ImmunoOnc19.
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VERY IMPORTANT COMMENT!!! #ImmunoOnc19 @UWCancerVaccine.
if presenters include NCT trial number.1) attendees can look at some of the perameters of trial (e.g. dosing).2) clinicians can find out that this presentation of findings exist.3) if there is a related trial (or an open arm), patients can find out more about trial. #ImmunoOnc19.
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Dr. Kandalaft points out that there are many types of antigens that can be used for vaccination, neo antigens of all types- not just point mutations. Target epigenetic changes, phospho Ag. etc. #ImmunoOnc19 @UWCancerVaccine
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Dr. Palucka highlights the importance of DC in mediating response to ICI. Recent Immunity paper implicated IFN-g and IL-12 in T cell DC cross-talk. #ImmunoOnc19 @UWCancerVaccine.
cell.com
Anti-PD-1 mAbs can induce sustained clinical responses in cancer but how they function in vivo remains incompletely understood. Garris et al. show that effective anti-PD-1 immunotherapy requires...
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Dendritic cells are the most important antigen presenting cells for stimulating T-cell responses to cancer. Nobel Prize winning tumor immunologist Dr. Ralph Steinman was honored for his work in this area. #ImmunoOnc19.
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Dr. Palucka highlights the issues associated with mutated antigen vaccines; the mutations have to be presented enodogenously in the patients MHC. Most are not. #Immunotherapy #immunoonc19 @UWCancerVaccine
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Surely there must be more data supporting a Phase III than just these 20 patients. !!!!#ImmunoOnc19.
Phase II arm of lenvatinib + pembro in urothelial ca. n=20 pts. ORR 25% (5 objective responses + 7 decreased tumor size that didn't meet criteria). But, significant treatment related AE's frequent, including a fatal GI hemorrhage. Phase 3 coming- what do you think? #ImmunoOnc19
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Many talks are associating PD-L1 tumor expression with clinical outcome- yet don't tell us definition of PD-L1 positivity. Is it 50%, 5%, 1%? On tumor? On immune "hot-spots"? on APC? Hard to figure out the utility of association. #ImmunoOnc19 @UWCancerVaccine.
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