Arshdeep Singh
@dr_singh_gastro
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Sikh, Punjabi, Gastroenterologist, Son, Father, Researcher, In love with poetry, Searching eternal happiness...🤟
Joined February 2022
RT @IJG_Journal: Revisiting thiopurines and therapeutic drug monitoring in IBD: Insights and implications in the Indian context. Editorial….
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💡 Why it matters:.DMC Index may enable early identification of CD in patients with PAF, even without bowel symptoms. This means timely therapy and possibly improved outcomes. @GKochharMD @bhardwaj_arshia @vandana_midha @DrAnuraagJ . 📖 Full study:
link.springer.com
Indian Journal of Gastroenterology - The radiological features of Crohn’s disease (CD)-associated and cryptoglandular perianal fistulae (PAF) are similar, but distinguishing them is crucial...
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Introducing the DMC Index: a MRI-based tool that helps identify CD-associated PAF using:.✅ ≥2 internal openings.✅ Rectal thickening.✅ Mucosal origin >1.85 cm from anal verge.A score ≥1.5 yields:.🎯 Sensitivity: 65%.🎯 Specificity: 94%.🎯 AUC: 0.88.
Magnetic resonance imaging to differentiate between Crohn’s disease-associated and cryptoglandular perianal fistula #IBD. 👉DMC index ≥ 1.5: strong discriminatory ability for CD-associated PAF. @dr_singh_gastro @bhardwaj_arshia @vandana_midha #DrAjitSood.
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Absolutely proud of @bhardwaj_arshia for carrying out this important work. This is more than data. It's a powerful message and a reminder that IBD in women is more than just inflammation. .
1/.🧵The Impact of IBD on Women's Health in a Low-Middle Income Country.Honored to present this important and underexplored work at #AOCC2025, under the mentorship of Prof. Ajit Sood & @dr_singh_gastro. #IBD #WomensHealth #GlobalHealth
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RT @doc_zubin: Does your country's GI society support Residents this way?. Indian Society of Gastroenterology probably does most for Reside….
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RT @IJG_Journal: Diffuse filiform polyposis in a patient with ulcerative colitis. @bhardwaj_arshia @dr_singh_gastro Dr Ajit Sood. https:/….
link.springer.com
Indian Journal of Gastroenterology -
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🔍 Colon full of fingers?.A rare case of diffuse filiform polyposis in a patient with ulcerative colitis. 📸 Colonoscopy & histology show classic features. 🧾 Read more @IJGJournal .#IBD #UlcerativeColitis #FiliformPolyposis.
link.springer.com
Indian Journal of Gastroenterology -
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🧵6/.🧩 Bonus Insight:.Even thiopurine-naïve patients did better on TOFA. Suggests we may need to rethink our default approach to post-IVCS maintenance in ASUC. 📚 Read the full article here:.🔗
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🧵5/.🛡️ Safety Profile.🔸 No patient discontinued therapy due to adverse events. 🔸 AZA → higher leucopoenia (15.4%).🔸 TOFA → mild herpes (6%), follicular acne (16%).No thromboembolic events or MACE reported.
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🧵4/.📊 Outcomes.✔️ Rehospitalization:.AZA 29% vs TOFA 0% (p = 0.003).✔️ Therapy Escalation:.AZA 22% vs TOFA 4% (p = 0.01).💊 Fewer flares, less escalation with TOFA!!.
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🧵3/.💥 Key Finding:.Event-free survival at 1 year:.🔹 AZA: 44%.🔹 TOFA: 75%.Log-rank p = 0.01.TOFA significantly outperformed AZA as maintenance therapy in steroid-responsive ASUC.
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🧵2/.🎯 Aim: To compare 1-year outcomes in ASUC patients responding to IV corticosteroids who were maintained on AZA vs TOFA. 🧪 Design: Propensity-score matched retrospective cohort.👥 N = 115 (AZA 65, TOFA 50).📍 India 🇮🇳.
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What's the best way to maintain remission after IV steroids in ASUC?.Our latest study compares Azathioprine (AZA) vs Tofacitinib (TOFA) in steroid-responsive ASUC. Published in @APTJournal 🔗 👇.
onlinelibrary.wiley.com
In this retrospective propensity-score matched cohort study of 115 ASUC patients responsive to IV corticosteroids, tofacitinib showed superior one-year event-free survival (75% vs. 44%, p = 0.01)...
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RT @APandT: "Azathioprine or Tofacitinib as Maintenance Therapy in Corticosteroid-Responsive Acute Severe Ulcerative Colitis" now published….
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🧬 Interesting findings on #IBD pharmacogenetics.🔹 TPMT polymorphisms found in 4.4% of patients.🔹 NUDT15 variants rare (0.22%), unlike East Asians.🧭 Genetic profile mirrors Caucasians, not East/South Asians.📝 Observations different from those in South India. Is it ancestry?.
New study reveals TPMT & NUDT15 gene variants in North Indians closely resemble those in Caucasians….Key insight for personalized thiopurine therapy in IBD #Genomics #PrecisionMedicine #IBD #India.@ Ajit Sood @dr_singh_gastro @sameenjoshi .
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RT @Bealoquebea: Understanding the complexity of chronic illnesses is no easy task. I created this figure with insights from patients to sh….
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RT @vandana_midha: Balancing acts: Navigating the landscape of medical education conferences .Indian J Gastroenterol. 2024 Jun 26.Arshdeep….
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RT @CCF_IN: Merry Christmas to everyone from CCF India!. Before we wrap up 2024, a gentle reminder to register yourself for the Season 2 of….
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Thank you sir. Coming from you means a lot. 🙏🙏.
Superb talk from @dr_singh_gastro outlining challenges of microbiome testing in clinical practice at 65th ISGCON
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