Dongrui Wang
@dow072109
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Postdoctoral Fellow, MD Anderson Cancer Center PhD from City of Hope National Medical Center Cancer Immunotherapy; CAR T cells
Houston, TX
Joined December 2013
RT @SaulPriceman: We got the Cover Story! #pricemanlab #CART #oncolyticvirus @cityofhope @anthonypark24 @DrStephenForman @SoCalYuman Effect….
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A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity
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Re-defining GBM classification!.An Integrative Model of Cellular States, Plasticity, and Genetics for Glioblastoma
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CSCs enrich for CD80 and inhibit T cell activity through CTLA-4 .Intrigued to see how much these cells alter in response to immunotherapy which is unfortunately not well elucidated here. Adaptive Immune Resistance Emerges from Tumor-Initiating Stem Cells
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RT @biorxivpreprint: Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustio….
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RT @nickhaining: Some lovely work from @MartinLaFleur18 in a new paper from Arlene Sharpe's and my labs in @naturecomms. Ever wanted to CR….
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Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity
cell.com
A combination of transcriptomics and mutational analyses in single cells from acute myeloid leukemia patients reveals the existence of distinct functional subsets and their associated drivers.
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Organoid-Induced Differentiation of Conventional T Cells from Human Pluripotent Stem Cells
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RT @SJMorrison_: We undermine the quality of our lives by torturing each other during peer review. Every #phd and #postdoc should be traine….
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NR4A depletion enhances CAR T cell function. Worth further investigation on how much of that effect comes from re-shaping endogenous immune response.
nature.com
Nature - Transfer of NR4A-deficient T cells expressing chimeric antigen receptors is shown to reduce tumour burden and increase survival by shifting T cell transcriptional programs away from...
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combining MHC-I/II KO and CD47 overexpression to generate hypoimmunogeneic iPSCs for allogeneic transplantation.
nature.com
Nature Biotechnology - Genetic engineering prevents immune rejection of allogeneic cell transplants derived from iPSCs.
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Mass Cytometry Analysis Reveals that Specific Intratumoral CD4+ T Cell Subsets Correlate with Patient Survival in Follicular Lymphoma
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Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping
cell.com
The hierarchical lineage of intestinal enteroendocrine cells is defined at a spatiotemporal single-cell manner and validated using organoid and in vivo models.
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Proliferation tracing with single-cell mass cytometry optimizes generation of stem cell memory-like T cells.
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RT @parkerici: Giving checkpoint inhibitor before surgery nearly doubles survival of #glioblastoma patients–new PICI #cancer #immunotherapy….
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Back to back studies on neoadjuvant anti-PD1 therapy followed by post-surgery treatment cycles. Important insights for treating tumors with low immune infiltrates. Interesting that tumor cell cycle status was strongly affected.
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Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma
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Noncoding regions are the main source of targetable tumor-specific antigens
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