Doug Portman ππ³οΈβπ𧬠@dougp.bsky.social
@doug_p
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U. Rochester prof studying sex diffs in #celegans neural circuits & behavior. Partner of the fab @mudblood. Food-obsessed. He/him. https://t.co/tEbw5p2ZmB
Rochester, NY
Joined November 2008
Bye, y'all, I'm out. Come find me on the other place! π¦ @ dougp.
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RT @susie_dent: Word of the day is βrecrudescenceβ (17th century): the return of something terrible after a time of reprieve.
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RT @URNeuroscience: πCongratulations to @PopovTori on receiving the prestigious F99/K00 NIH BRAIN Initiative Diversity Specialized Predoctoβ¦.
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Listen to this winner of the Nobel Prize-ala!.
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Huge congratulations to my friend and colleague @NathanASmith1 on his new position. Nathan's energy and enthusiasm for mentoring make him exactly the right person for this, and it's great to see @URochester_SMD devoting resources to this critical component of biomedical research.
β¨ππ‘ππ«ππ©ππ£π πππ¨πππ§ππ πππ£π©π€π§π¨πππ₯ ππ© πππΏβ¨. @NathanASmith1 is taking on a new role as Associate Dean for Research Mentorship!. He will work with the research community to strengthen practices and support each individualβs career growth.
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RT @NathanASmith1: I am honored to take on the role of inaugural Associate Dean for Research Mentorship at the School of Medicine and Dentiβ¦.
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It was a pleasure and honor to talk with the thoughtful and engaging @JohnnyFoxe about the amazing nematode #celegans and the work weβve been doing in the lab. If youβve got half an hour to kill and want to hear me blather on about worms, give it a listen!.
What happens in the male C. elegans brain when the urge to find a mate overrides the basic need to eat? And how can these insights inform our understanding of sex differences in human health and disease susceptibility?.π Listen to the latest Neuroscience.
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Congratulations to the newly minted Dr. Gregory Reilly! Greg successfully defended his thesis last week and we're writing up his work on sex differences in #celegans behavioral states now. #ceneuro24 folks will get a sneak preview next week!
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Feeling honored and humbled to be among this group of amazing scientists!.
Congratulations to the newest @aaas fellows @UofR! Including our own @doug_p of @URMCBMG #URochesterResearch
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Finally, thanks to the many people who provided feedback and suggestions on this work, and to the intrepid worm researchers who laid the foundation without which these studies would have been impossible!.
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Read the paper for many more interesting tidbits! π.
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While we've known about signals that males use to find hermaphrodites for a while, this work teases apart the contributions of these signals in a more natural context and helps us better understand what's important to males when choosing a mate.
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Unexpectedly, we find that the ASH neurons (known for detecting aversive stimuli in hermaphrodites) have a role in male attraction to ascaroside sex pheromones. This may be related to sex differences in ASH's physiology or connectivity (see .
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At least some of this reflects sex differences in sensory function, consistent with previous work from our group (e.g., and others.
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Mate preference is also sex-specific: only males prefer to interact with hermaphrodites. But if we genetically masculinize a hermaphrodite's nervous system, these animals are now attracted to other hermaphrodites.
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We don't know exactly how males distinguish these features, but this involves multiple cues - ascarosides and other, unknown ones that will be interesting to identify.
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It makes sense that males would have these preferences - they likely help promote the number and health of their progeny. This says that some hermaphrodite cues are probably honest indicators of fitness.
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But males can also distinguish other features of potential mates! They prefer well-fed over food-deprived hermaphrodites. They also prefer virgins over hermaphrodites that have previously mated with another male.
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