Dominic Burrows 蔚松
@dominicburrows_
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Computational Neuroscience & Genomics | Lecturer in Data Science | Postdoc with @emukamel at UCSD.
San Diego, USA
Joined August 2018
Ever wonder how the brain manages to be BOTH adaptable to environments AND stable to perturbations? . and how on earth this is achieved during development when plasticity is high? . Check out my & @roschkoenig preprint and see if we have any idea:
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RT @takaki_komiyama: 663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that s….
biorxiv.org
During the execution of learned motor skills, the neural population in the layer 2/3 (L2/3) of the primary motor cortex (M1) expresses a reproducible spatiotemporal activity pattern. It is debated...
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RT @dominicburrows_: Ever wonder how the brain manages to be BOTH adaptable to environments AND stable to perturbations? . and how on eart….
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How does this fit together? The tel produces more diverse patterns across dev. & at the same time stronger attractors emerge ensuring robustness. The brain may organise close-ish to criticality to be flexible, remaining sufficiently subcritical to allow reliability.
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To understand the dynamical regimes that could drive such rotational stability we built a Kuramoto oscillator model - using this we found that rotational stability could co-occur with a transition from neutral, critical dynamics to slightly subcritical, stable dynamics
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Criticality is expected to be weakly attracting, prioritising flexibility over stability. Surprisingly, we found that tel showed an emergence of rotationally stable dynamics, driven by stable relative activity patterns, maintained up to 5 seconds into the future!
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In fact, propagating 'avalanche' dynamics in the telencephalon seemed to resemble scale invariant functions across development - this is a key marker of critical dynamics which support flexible dynamics!
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We did in vivo 2p imaging to record single neuron activity in larval zebrafish from 3-8 days, across 10-30,000 neurons. This is a critical period for synapse turnover and formation of hunting behaviours. The telencephalon stood out for its markedly increased excitability!
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Pleased to say that I have been appointed as a Lecturer in Data Science at @UCSanDiego for next year - excited to get started :D.
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It's been a long-held dream of mine to publish in a physics journal - excited to see this finally out at @PhysRevX, credit to the excellent @roschkoenig @ArianAshourvan , @ChrisWLynn.
This is out now in @PhysRevX - how whole-brain activity patterns arise from pairwise interactions in the larval zebrafish 👉📖 .
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RT @catia_fortunato: Really excited to attend SfN for the first time! #SfN23 I will share our work on nonlinear manifolds, and how we are p….
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Super excited to be back @SfNtweets in DC! Will be giving a talk on transposable elements in the brain at NANO13.04, come check it out!
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Exciting work from the incredible @roschkoenig @ArianAshourvan @ChrisWLynn , honoured to be involved!.
Complex patterns of brain activity emerge from direct one-to-one neuronal interactions. Is this simple scaffold enough to explain whole-brain patterns in real life data?.Come with us and see: ✨ collab with @dominicburrows_ @ChrisWLynn & @arianashourv
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RT @roschkoenig: Complex patterns of brain activity emerge from direct one-to-one neuronal interactions. Is this simple scaffold enough to….
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RT @klagojohn: So the time came to bid farewell to @dev_neuro, but also the end of an era for me in academic research. .
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RT @roschkoenig: This really was a labour of love by @dominicburrows_ great to see it out properly at @SfNJournals . Read on for whole-bra….
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Check out the original tweetprint for more details:.
Delighted to have my preprint finally out! We show that synaptic EI imbalance drives whole brain dynamics away from a phase transition into chaos - these supercritical dynamics can explain impaired computation in epileptic seizures.
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creds to the whole amazing team @roschkoenig @GiovannDiana @DaniSBassett @MartinMeyerTBP @epilepsy_london @birgitpimpel.
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Propagating neuronal avalanches give rise to chaotic and sticky dynamics at the macroscale during epileptic seizures ❤️🔥❤️🔥❤️🔥. Pleased to say that my paper is now published @SfNJournals .
jneurosci.org
Neuronal activity propagates through the network during seizures, engaging brain dynamics at multiple scales. Such propagating events can be described through the avalanches framework, which can...
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