Dieter Edbauer
@dieter_edbauer
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#FTD #ALS scientist at @DZNE_de and @SyNergy_Cluster focusing on C9orf72 and TDP-43. Trying to go all the way from the ultra-structure to translation.
Munich, Germany
Joined December 2017
Lust auf anwendungsorientierte Wissenschaft? Am DZNE München suchen wir ab sofort eine(n) TA für unser GA-VAX Projekt. Deine Arbeit könnte direkt in klinische Studien mit #C9orf72 #ALS Patienten einfließen. Jetzt bewerben und Teil des Teams werden! #Jobs
https://t.co/qDSNZefM5D
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I am grateful for EIC Transition funding that will allow @DZNE_en and @Intravacc to develop our anti-GA vaccine prototype to the point where it can be tested in C9orf72 ALS patients. Looking for Postdoc/PhD students in Munich @Synergy_cluster @EUeic
dzne.de
The vaccine is targeting the most common genetic ALS variant.
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Three nucleoside analogs block BIDIRECTIONAL transcription of the expanded C9orf72 repeat. We are working to make chronic therapy safe in patients. Thanks for the great collaboration! @DZNE_en @LMU_Muenchen @CarellThomas
https://t.co/yXikT2Z7p3
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TDP-43 CTF forms gel-like inclusions and sequesters stalled proteasomes in neurons. #ALS mutants impair proteostasis even more. #CryoET study with @ruferbus and @QiangGuo_EM.
biorxiv.org
TDP-43 inclusions enriched in C-terminal fragments of ~25kDa (“TDP-25”) are associated with neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here, we...
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