David Tingley
@davidwtingley
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interested in biological systems; he/him; founder @ Olio Labs
Joined September 2017
and so begins my journey into the rest of the body! There are a few things I really loved and learned during this study…. a thread… 1/n.
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Some really cool work we've been doing @OlioLabsInc. New science opens the door to better medicines.
Sex differences in GLP-1 signaling across species #biorxiv_sysbio.
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RT @biorxiv_sysbio: Sex differences in GLP-1 signaling across species #biorxiv_sysbio.
biorxiv.org
Two billion humans are currently overweight or obese[1][1]. Glucagon-like peptide 1 receptor (GLP1R) agonists have emerged as the most promising treatment for this epidemic, however, the side effects...
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RT @OlioLabsInc: Check out what we're working on at Olio Labs!. 70% of patients taking GLP-1's (like Ozempic) are women, but they experienc….
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Congrats to Xuefeng and the authors on a great paper. Sometimes things do line up between species
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RT @JCarpenter___: Had a blast discussing my data with experts who’ve spent *decades* studying/modeling the HPC-EC circuit! Whether it's fl….
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RT @JCarpenter___: At @FENSorg this year?. Poster #PS01-26AM-004 (WED). Presenting my work on remapping of neural populations across the HP….
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RT @dlevenstein: Happy to share a new preprint - the culmination of the past three years of postdoc with @tyrell_turing and @apeyrache, and….
biorxiv.org
The mammalian hippocampus contains a cognitive map that represents an animal’s position in the environment [1][1] and generates offline “replay” [2][2],[3][3] for the purposes of recall [4][4],...
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RT @JCarpenter___: Big picture: The hippocampal field has been talking a lot about how place cells might be ego-tuned to points/goals in th….
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RT @JCarpenter___: So, feature or bug? Our study quantifies the degree of egocentric tuning in our data vs. how much we can attribute to th….
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RT @JCarpenter___: We recorded neurons from rats in the open field and found that when we used field-standard approaches, more than HALF of….
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RT @JCarpenter___: To figure out why we couldn't see any of this tuning by eye (like the beautiful pinwheel patterns you see in RSC, postrh….
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RT @JCarpenter___: To simulate these cells, we used real rat foraging behavior (86 sessions worth!)
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RT @JCarpenter___: After depleting the Moser lab's compute resources (thanks IDUN), we found staggering false positive rates. Even under….
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RT @JCarpenter___: Most noteworthy was that when we increased out-of-field or place field size, the false positive rates exploded! We think….
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RT @JCarpenter___: To mitigate these false positives, we (1) tested the cells against a null distribution that accounts for position-HD dep….
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RT @JCarpenter___: Result: 4.5% of the cells were EB modulated, and only 2 of those cells were stably-tuned across sessions! .
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RT @JCarpenter___: Our results suggest that:.* ego-tuning may have been drastically over-estimated in the past and. * that statistical appr….
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🚨Super cool paper alert 🚨.
TLDR; We only found *two* neurons in our CA1 dataset that are egocentric-modulated 👀. My first @biorxivpreprint (and the first part of my PhD work) is live!. #tweeprint
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RT @IpshitaZ: I am on the job market this year! My lab will study how the brain creates a internal model of the external world that is flex….
ipshitazutshi.com
I am a systems and circuits-level neuroscientist interested in understanding how the brain builds memories and perceptions that change with fluctuating motiv...
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Super excited to announce this. Reach out to founders@oliolabs.co if you want to learn more!.
Some life news: @davidwtingley and I recently launched Olio Labs with backing from @SciFounders and @ycombinator ! . You can read about it here: . Let's build!.
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