Dziugas Sabonis
@d_sabonis
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RT @hauryliuk: Hidden in plain sight: Bacterial genomes reveal thousands of lytic phages with therapeutic potential
biorxiv.org
Phages are typically classified as temperate, integrating into host genomes, or lytic, replicating and killing bacteria. Lytic phages are not expected in bacterial genome sequences, yet our analysis...
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RT @HarvardMicro: Research from Renee Chang @reneechang explains how viruses disrupt His-ADPR immune signaling. Kranzusch lab ( https://t.co….
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Excited to share our latest on the Type II Thoeris system! In collaboration with the Sorek and Kranzusch labs, we identify His-ADPR as a signaling molecule. Huge thanks to all involved—amazing teamwork!.
nature.com
Nature - In response to phage infection, the Toll/interleukin-1 receptor (TIR) domain protein ThsB of the type II Thoeris defence system produces histidine conjugated to ADP-ribose, which...
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RT @hauryliuk: Registration for our PhD / postdoc course 'Fundamentals of Basic and Applied Phage Biology' is now open! See you in Lund May….
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RT @IlyaOsterman: Our NAD-reconstitution story is finally published in @nature. Thank you to all co-authors, espec….
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RT @SorekLab: More details on the discovery, led by super talented @IlyaOsterman, are in the thread below.
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RT @eigie111: Exited to announce the publication of our work showing that activated type I Thoeris SIR2 effector ThsA forms helical filamen….
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Our take on Thoeris type I system. Glad to see these right-handed spirals in (N)nature. 🧬.This work was led by Giedre Tamulaitiene (@eigie111) in collaboration with @SorekLab.
nature.com
Nature - A study reports that the Theoris anti-phage defence system is activated through helical filament assembly of the ThsA effector and details the activation mechanism.
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