NIH Pragmatic Trials Collaboratory
@Collaboratory1
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Supported by @NIH, the NIH Pragmatic Trials Collaboratory is advancing the design, conduct, and dissemination of pragmatic clinical trials.
Joined October 2012
ICYMI 📣 On September 5, we'll welcome Dr. Robert Califf for a special edition of our Rethinking Clinical Trials Grand Rounds to discuss "The Non-Learning Health System." #pctGR
rethinkingclinicaltrials.org
Speaker: Robert Califf, MD Instructor in Medicine Duke University Medical Center Former Commissioner of Food and Drugs Title: The Non-Learning Health System Date: Friday, September 5, 2025, 1:00-2:00...
📅 Save the date—On September 5, we'll welcome Dr. Rob Califf, former FDA commissioner, for an engaging conversation about "the non-learning health system." Join us for this special edition of Rethinking Clinical Trials Grand Rounds! #pctGR. Learn more ➡️
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📣 In this Friday's Rethinking Clinical Trials Grand Rounds, we'll hear from Emily O'Brien of @DukeMedSchool about the recently published @PCORnetwork Playbook and how it can support the design of pragmatic clinical trials. Join us! #pctGR. 🔗
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In a new analysis from INSPIRE, an NIH Collaboratory Trial, automated prompts to improve antibiotic selection for hospitalized patients led to sustained reductions in the use of extended-spectrum antibiotics throughout the hospital stay. 💡
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RT @PCORnetwork: Calling all clinical researchers 🔬📣. This Fri. Aug. 22 at 1 pm, join @collaboratory1 Rethinking Clinical Trials Grand Rou….
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Our HiLo trial, supported by @NIDDKgov, sought to determine the optimal serum phosphate target for patients undergoing #hemodialysis. Though the study was stopped early, it offers important lessons for future pragmatic clinical trials. Read more ➡️
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🎙️ In the latest episode of our Rethinking Clinical Trials Podcast, Pearl O'Rourke and Dave Wendler of our Ethics and Regulatory Core discuss keeping participants informed in #pragmatictrials that use waivers of informed consent. #bioethics. Listen ➡️
rethinkingclinicaltrials.org
In a new episode of the Rethinking Clinical Trials Podcast, Pearl O’Rourke and Dave Wendler discuss their recent publication, “Disentangling Informing Participants From Obtaining Their Consent.��...
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📣 In this Friday's Rethinking Clinical Trials Grand Rounds, Tim Walsh, Chris Weir, and Richard Parker of @UsherInstitute will present the A2B trial of sedative medications for critically ill patients receiving mechanical ventilation. Join us! #pctGR. 🔗
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RT @PCORnetwork: 🔍 Researchers who partner with PCORnet® have access to data and expertise that can’t be found anywhere else. We designed….
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📚 We've got content! The newest section of our Living Textbook of Pragmatic Clinical Trials describes the complexities of integrating evidence-based interventions into clinical care in pragmatic research embedded in healthcare systems. Learn more ➡️
rethinkingclinicaltrials.org
The NIH Pragmatic Trials Collaboratory Implementation Science Core, led by Devon Check and Hayden Bosworth, has developed a new chapter on implementation to assist study teams with the complex...
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📣 In this Friday's Rethinking Clinical Trials Grand Rounds, Eden Evins of @harvardmed and @MGHPsychiatry will present results from a randomized trial of varenicline for youth nicotine vaping cessation. Join us! #pctGR. 🔗
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📅 Save the date—On September 5, we'll welcome Dr. Rob Califf, former FDA commissioner, for an engaging conversation about "the non-learning health system." Join us for this special edition of Rethinking Clinical Trials Grand Rounds! #pctGR. Learn more ➡️
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RT @DCRINews: Check out the latest @Collaboratory1 Rethinking Clinical Trials Podcast episode, featuring DCRI Faculty Lesley Curtis and Kei….
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At our 2025 Annual Steering Committee Meeting, a panel of pragmatic clinical trialists shared strategies for monitoring and documenting changes in usual care. Learn more ➡️
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🎙️ In the latest episode of our Rethinking Clinical Trials Podcast, Lesley Curtis and Keith Marsolo of @DukeMedSchool discuss a new learning module on healthcare data interoperability and standardization for research. Listen now ➡️
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📣 In this Friday's Rethinking Clinical Trials Grand Rounds, Jon Tilburt and Andrea Cheville of @MayoClinic will present initial outcomes from NOHARM, an NIH Collaboratory Trial. Join us! #pctGR. 🔗
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Decisions about whether to integrate digital tools into the EHR for #pragmatictrials hinge on 4 critical factors: complexity, institutional governance, requirements for integration, and involvement of personnel. Learn more:
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RT @Collaboratory1: In this Friday's session of our Rethinking Clinical Trials Grand Rounds webinar, @DukeMedSchool's Adrian Hernandez and….
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Features of the external environment during online medical group visits and interacting with the technology itself emerged as key themes in interviews with patients participating in OPTIMUM, an NIH Collaboratory Trial. Learn more ➡️
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In this Friday's session of our Rethinking Clinical Trials Grand Rounds webinar, @DukeMedSchool's Adrian Hernandez and Rebecca Sullenger will lead a panel discussion on a recent analysis of and the state of clinical trials. ➡️
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Engaging with community partners can enrich and inform research through the lifespan of a clinical trial. NIH Collaboratory investigators shared tips for building these relationships at our 2025 Annual Steering Committee Meeting. Learn more ➡️
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