Chiarle lab
@chiarlelab
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Official account of Roberto Chiarle's laboratory @BostonChildrens and @unito
Boston/ Torino
Joined February 2022
Not easy to encompass the growing importance of #ALK in cancers and the progress in treating ALK+ tumors, but this Review might help @chiarlelab @NatureRevCancer @BostonChildrens @unito .
nature.com
Nature Reviews Cancer - ALK genetic alterations drive various malignancies through aberrant tyrosine kinase activation, promoting oncogenic cell growth and survival. Here, Voena et al. outline...
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RT @KathleenHBurns: These experiments reveal the full extent of DNA damage caused by L1 expression. The retroelement that built our genome….
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RT @AmbrogioLab: Our latest publication online now! @NatureComms .Amazing team work @lab_santamaria @MJNokin @Biagi….
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RT @KathleenHBurns: Very exciting opportunity to join the faculty @BWHPath :.bwh pathology professsor opening - Google Search https:/….
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Fantastic collaboration with @maddanilo and the @genentech team for our review on SHP2 just out @CD_AACR .
aacrjournals.org
AbstractThe protein phosphatase SHP2/PTPN11 has been reported to be a key modulator of proliferative pathways in a wide range of malignancies. Intriguingly, SHP2 has also been described as a critical...
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RT @AmbrogioLab: Thanks a lot @CICancer_com for hosting the first RAS Initiative Europe event #TargetingRAS, we enjoyed three days of amazi….
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Check out our paper on @ScienceTM that deciphers how to overcome ALK TKIs resistance in ALK+ lymphoma by targeting the CCR7-PI3Kgamma pathway. Congrats to all the talented scientists that helped the work! It's on the cover! @BostonChildrens @unito .
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RT @peter_j_park: Many others contributed, including many current and former members of my lab, especially @isidrolauscher. Taek from the R….
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RT @LUNGevity: It is such an honor for us to partner with .@ALK_Research & @ALKLungCancer to fund research most meaningful to the ALK commu….
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RT @BCH_Innovation: A caution on CRISPR in @NatureComms, and the suggestion that base editing and prime editing may be safer from @jianli_t….
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Our work on LINE-1 insertions at CRISPR editing sites is already out! Congratulations to Jianli Tao (@jianli_tao) and Qi Wang (@flying_gene) @chiarlelab. Many thanks to our collaborators from @KathleenHBurns to help to make it possible.
And @jianli_tao @flying_gene & co in @chiarlelab at @BostonChildrens @harvardmed explore the frequency & mechanism of LINE-1 insertions at #CRISPR editing sites .
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RT @LeciaSequist: Jonathan Riess says that the future of immunotherapy in mutation-driven lung cancer is vaccines - I hope this pans out, f….
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Nice comment about our recently published paper in @BloodJournal from Karaca-Ataby et al.@atabay_karaca Thanks to Dr. Ryan Wilcox for highlighting our work.
Getting ALK inhibitors SHPshape
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Nice comment about our recently published paper in @BloodJournal from Karaka-Atabay et al. Thanks to Dr. Ryan Wilcox for highlighting our work.
Getting ALK inhibitors SHPshape
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