Charlie Arber
@celarber
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👨🔬 🏏 🏉 ⛳️ 🎾 Stem cell biologist. working on understanding mechanisms of dementia. neurons. astrocytes. microglia.
UCL, London, UK
Joined March 2013
More than just making amyloid. What if mutations in PSEN1 also predispose inflammation. We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. @WrayLabUCL @AlzSocResearch .🧵/6.
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RT @limberger_chris: I’m glad to see this masterpiece on astrocyte biology finally out in @NatureNeuro! Huge congrats to the team @AlSerran….
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RT @InterestingSTEM: The “Universe 25” experiment, conducted by American scientist John Calhoun, is one of the most alarming studies in the….
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It was brilliant talking to @demrescommunity and @aitanasogorb about our work on FBD with @lecrawf0. A disease you’ve probably never heard of, but it might teach us a lot about dementia. Thank you to @racingdementia and @ARUKscientist for the support.
Familial British dementia decoded! 🧬 @aitanasogorb talks with UCL’s @celarber & @lecrawf0 about unique genetic insights & research advancements, and new funding from @racingdementia #Dementia.
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RT @demrescommunity: Familial British dementia decoded! 🧬 @aitanasogorb talks with UCL’s @celarber & @lecrawf0 about unique genetic insight….
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RT @BarnsleyMuseums: Today is #AdaLovelaceDay Prof @SelinaWray grew up in Barnsley and now leads a group of dementia researchers at Univers….
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RT @VernonLab_KCL: Fully funded #PhD #organoids #psychedelics - details below ⬇️ only ONE more week to apply, don’t delay and please share….
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RT @SGoldsmith0: Always exciting to get images like these 😁🧠 first go at whole mount staining of organoids in the first image!🧫 https://t.c….
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RT @SGoldsmith0: It’s been an amazing few days at the @isftd conference in Amsterdam so far! 🧠 I am very excited to have the fantastic oppo….
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4.94km (lap 6) done. 🏃 .#singaporeGP .@racingdementia . #WorldAlzheimersDay . Still some laps left. Please consider signing up today.
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Huge thanks to @SelinaWray @PataniLab @ARUK_UCL_DDI @ojziff @nsetsalvia @DervisSalih1 and funders @AlzSocResearch.
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Perhaps inflammation is key to disease onset? Aligning familial and late onset AD via a 2-hit model of fAD. Feedback and new collaborations really welcome!.
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4. Finally, we can confirm this role for PSEN1 in cytokine signalling using gamma-secretase modulators which lower the astrocyte response to inflammatory cues.
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3. Under basal conditions, PSEN1 mutant astrocytes have an inflammatory phenotype. This is driven by TNF, NFKB and most notably JAK-STAT signalling (STAT2).
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2. Genes involved in membrane proteolysis are disrupted in PSEN1 mutant astrocytes.
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1. PSEN1 cleaves hundreds of substrates including many cytokine receptors. We find PSEN1 is involved in the astrocyte response to cytokine stimulation (which is not the case in neurons). This upregulation is disrupted by familial AD mutations in PSEN1.
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I'm running lap 6! . Please consider signing up for Run Singapore, there are still laps that need volunteers! 🏃♀️🏃♂️. @racingdementia.
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RT @DervisSalih1: Excited to share our new work: genetic risk analysis on Chromosome X for Alzheimer’s disease. Implications for risk in me….
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