RT @ryanayork: Phenotypes often arise from linear + nonlinear genetic relationships. Neural networks should be great at modeling this. Resu….

RT @ryanayork: Biological foundation models have hit a plateau. Scaling isn't working as expected. Foundational concepts from evolutionary….

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This work highlights why genetic background matters in model organisms! Even after multiple rounds of backcrossing, unexpected phenotypes can emerge that may not be directly related to the gene you're studying. @ArcadiaScience [9/9].

To figure this out, we're testing another CPC1 mutant (cpc1-2) from a different genetic background and trying to rescue both with wild-type CPC1 expression. This should tell us if these growth phenotypes are due to the mutation or genetic background. [8/9].

Why does cpc1-1 behave so differently? It might be retaining genetic material from its parent strain despite backcrossing. Or maybe the CPC1 protein itself plays a role in metabolism - it does interact with enolase and other glycolytic enzymes! [7/9].

Third, after 47 days, cpc1-1 was the ONLY strain that could grow on marine medium with high salt content, revealing an unexpected halotolerance. [6/9]

Second, on nitrate-containing media, wild-type C. reinhardtii and ida4 showed chlorosis (yellowing) as expected due to their nit2 mutation. But cpc1-1 maintained dark green colonies, suggesting it can use nitrate efficiently. [5/9].

First, cpc1-1 showed enhanced growth on media with proteose peptone, outperforming wild-type strains that barely grew in this condition! [4/9]

The cpc1-1 mutant (which has defects in the central pair complex of flagella) showed three surprising growth phenotypes that weren't present in other strains, including the ida4 mutant (which has inner dynein arm defects). [3/9].

We were studying flagellar mutants as models for human ciliary diseases when we noticed something odd about their growth patterns. So we decided to compare growth across different media types to see if these mutations affect metabolism beyond just flagellar function. [2/9].

Discovered some unexpected growth phenotypes in Chlamydomonas flagellar mutants! The cpc1-1 strain (with central pair complex defects) shows surprising metabolic traits that might be independent of its flagellar defects. 🧵 [1/9].

RT @KarasLab: Our newest preprint. Congrats @ejlwalker and all authors in collaboration @Th_Mock 🔹 Fast electroporation & PEG methods 🔹Deli….

RT @GeorgeSandler_: Check out our new pub, "Predicting antimicrobial resistance phenotypes across 7,000 E. coli genomes" where we do a deep….

RT @bentbraverman: Introducing our new pub, “DIY Raman spectroscopy for biological research”! We optimized an open‑source Raman system for….

RT @seemaychou: Zoogle! Our new tool from @arcadiascience for picking research organisms. Even if you’re not a scientist, you should care t….

RT @ArcadiaScience: Happy Darwin Day! Today we’re thinking about how to use evolution to accelerate biomedical research. We think the answe….