Catherine Hurd
@catherine_hurd
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Chemical biologist / University of Manchester
Joined January 2021
Very happy to share my latest work in the @lwalport in collaboration with @MAChristoLab now out in @NatureComms. Thanks so much to all the co-authors for their contribution to the project. #chembio #cyclicpeptides #citrullination #PADI4
nature.com
Nature Communications - Walport & coworkers report cell-active, potent and selective cyclic peptide modulators for the enzyme peptidylarginine deiminase PADI4/PAD4, including an inhibitor,...
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Now out in print: https://t.co/ohMMteC276 See Maria's thread below for a nice summary of what we got up to and let us know if you'd be interested in trying out any of our new tools for probing the function of PAD4/PADI4
We are very happy to share the result of a wonderful collaboration with @lwalport lab, on the development of a new suite of PAD4/PADI4 modulators A cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation
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Pleased to share this preprint of our latest work to incorporate an unmasked covalent warhead into mRNA display libraries
Discovering Covalent Cyclic Peptide Inhibitors of 2 Peptidyl Arginine Deiminase 4 (PADI4) Using mRNA3 Display with a Genetically Encoded Electrophilic 4 Warhead https://t.co/rNOG9gYpYh
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Really pleased to share my postdoc work with GSK and @lwalport which is now published in Angewandte!
mRNA Display in Cell Lysates Enables Identification of Cyclic Peptides Targeting the BRD3 Extraterminal Domain (Louise J. Walport and co-workers) @lwalport #openaccess
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Registration is open for the RSC PPSG Early Stage Researcher Meeting in Edinburgh on 6th September Reserve your place now! https://t.co/eR0Za6scWC
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Fans of proteins and peptides, join for the next PPSG seminar! I will be talking about my work in @lwalport lab, developing cyclic peptide tools for challenging protein targets using mRNA display 🧬
Join us for the next PPSG online lunchtime seminars from @Catherine_Hurd (Manchester) and Fabian Rehm (Cambridge). Register at: https://t.co/hx1JUymwRh
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🚨Job Alert🚨 We're looking for a chemist to join our lab. Working as part of our cPTM DISPLAY team (ERC starting grant selected/UKRI funded project https://t.co/y9IF5t5zaT). 2 year postdoc position based @TheCrick and @impchemistry
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We believe that this approach will be useful for identifying tool molecules for proteins that are challenging to purify e.g. those with intrinsically disordered regions or that are prone to aggregation
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So pleased to share that my Postdoc work with @lwalport and GSK (@Jake_T_Bush, Andy Powell) is now available on bioRxiv! Here we have used mRNA display to identify high-affinity cyclic peptides for non-purified protein targets in mammalian lysates 🧬🧫
biorxiv.org
mRNA display is a powerful technology to screen libraries of >10[12][1] cyclic peptides against a protein target, enabling the rapid discovery of high affinity ligands. These cyclic peptides are...
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Check out the review that @cassandrak94 and I wrote, where we've discussed the current state of fragment-based drug discovery targeting the ubiquitin system! We're very excited to see it published 🎉 👩🔬 @KatrinRittinger @TheCrick
https://t.co/Fscw93IkLh
frontiersin.org
The ubiquitin system contains a wealth of potential drug targets for many diseases and conditions, including neurodegenerative, immune, metabolic and develop...
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It’s only 1 week until the @RSC_PPSG online seminar series begins! ⏰ Don’t forget to join us at lunchtime (1 pm UK time) on Friday 7th October for some exciting science and a chance to network. Event details and registration are available below: https://t.co/wOQL4IxMq8
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⚠️😡Make no mistake, we are angry. This Government has today launched an attack on nature. We don’t use the words that follow lightly. We are entering uncharted territory. Please read this thread. 1/13
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We face an urgent nature and climate crisis. But instead of a plan for nature's recovery on land and at sea, the UK Government is pursuing a dangerous agenda of deregulation that puts the very laws protecting wildlife at risk. But what does this mean exactly? (1/12)
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We share the deep concern of our fellow conservation organisations during this critical moment for nature. We have been and will continue to help drive the national conversation until assurances are made for the protection of nature and history for generations to come.
Statement on recent Government proposals and the importance of environmental protections - National Trust https://t.co/jyzc5dZeYo via @nationaltrust
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Just a reminder that our upcoming @RSC_PPSG lunchtime online seminar series starts on 7th October @ 1 pm with two excellent speakers @Thomson_Lab & @TheRubiniGroup. Register below: https://t.co/krvwZGHMJv
🌟 Our first @RSC_PPSG online seminars are from @Thomson_Lab at @UofGChem and @TheRubiniGroup at @ucdchemistry on Oct 7th 1 pm encompassing binder design and PTM analysis (!).🌟 Please register this online lecture!
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Check out this exciting opportunity for a postdoc in Chemical Biology working as part of the Crick/GSK collaboration! I’ve worked within the collaboration for nearly 2 years now and couldn’t recommend it highly enough - happy to answer any questions 😄
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Grateful to @BritPharmSoc & @ELRIG_UK for the opportunity to co-chair a session at their New Modalities in Drug Discovery conference at @TheCrick - a great experience and a fantastic line up of talks over the 2 days 👏🏻👏🏻 #drugdiscovery #ELRIG
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I'm looking forward to chairing a session at @BritPharmSoc & @ELRIG_UK's joint meeting, 'New Modalities in Pharmacology & Drug Discovery'. Join in at @TheCrick, 4 - 5 July 2022. Register for free now: https://t.co/tZ4XpRePxo
#NewModalities #Pharmacology #DrugDiscovery
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