Pam Cai
@cai_pam
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Arnold O. Beckman Postdoctoral Fellow in Tirrell Lab @UChicagoPME. ChemE PhD in Spakowitz + @heilshornlab @Stanford. BS @MITChemE.
Joined September 2011
Friends, please help spread the word about our microbiology REU program at Montana State University. https://t.co/FdW3gWQDRd Each student receives a stipend ($7000 for 10 wks). Travel compensation, room, and board are also provided. Details in the attached pic--Feb 13 deadline
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The (virtual) Rising Stars in Soft and Biological Matter Symposium is this Wed 12/11 & Thurs 12/12, and it's an amazing line up of speakers! I'm honored to be selected as a Rising Star this year along with the amazingly accomplished group. Register here:
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Congratulations Manish on publishing this super cool work 🎉 I remember how intrigued I was when I first saw your videos of the “cell tumbling” and am honored to have been a part of this journey!
Happy to share our work out now in @NatureMaterials! We (fortuitously) identified an intriguing cell movement that occurs in 3D hydrogels in the minutes timescale and can regulate mesenchymal stem cell (MSC) differentiation. We call it ‘cell tumbling’. 🧵 https://t.co/QP7H3y5pfd
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🎉 Congratulations to PhD student Michelle Huang (@michshuang) for receiving ✨ 1st place ✨ in the Area 8B Biomaterials Graduate Student Award Session @ChEnected, sharing her work on protein-engineered hydrogels to control neural progenitor cell stemness! @StanfordEng
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Hey ChemE friends! I and my fellow Tirrell Lab mate @Siyang_Wang_ will be at #AIChE2024 AND we're both on the faculty job market. Check out our posters (I'm at 103, Siyang at 375) and talks! See you soon in San Diego! #AIChEAnnual @ChEnected
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pf phage entangle cilia and mucins, preventing mucociliary clearance. Congratulations to @ebburgenerMD @PRSecor @cai_pam @heilshornlab and Carlos Milla on this lovely work! https://t.co/Va1a3EoOU5
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📢 Just out in @PNASNexus - our latest publication showing that Pf phage entangles cilia and slows mucociliary clearance in two airway models! #pulmtwitter #cysticfibrosis @cf_stanford @StanfordCEPB @bollyky @cai_pam @ChildrensLA @CF_Foundation
academic.oup.com
Abstract. Pseudomonas aeruginosa is a major pulmonary pathogen causing chronic pulmonary infections in people with cystic fibrosis (CF). The P. aeruginosa
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Thank you Andy! Congratulations to you as well on your ACS Global Outstanding Mentor Award though it should really be shared with @HeilshornSarah. I have benefitted tremendously from the mentorship and support you both provided and couldn’t have asked for better advisors!
I am delighted to share that Pam Cai received the ACS Global Outstanding Graduate Student Award at the ACS meeting in Denver earlier this week. Congratulations for all your research achievements and for this well-deserved recognition. @cai_pam
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Hello chemistry friends! I’ll be presenting my PhD and postdoc work at #ACSFall2024 today and tomorrow. Come tune in!
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Great to see the work Vanessa and Brian did with me all summer presented so well by them! I’m very proud of how much my undergrads have learned and accomplished in such a short time.
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I’m so inspired by amazing talks and discussions I’ve seen and had this week first at #GRCPolyPhys then at #BeckmanSymposium Thanks to all the organizers @GordonConf @arthijayaraman Rachel Segalman @BeckmanFnd for all their hard work! Now I can finally sleep 😅
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After two Army deployments to Iraq, @rsnavarro425 aspired to be a physician before a chance encounter on a university campus led him to study biomaterials. Learn more about his career journey: https://t.co/ov9neun3lj.
#ASBMBMOSAIC #NIHMOSAIC
asbmb.org
After two Army deployments to Iraq, Renato Navarro aspired to be a physician before a chance encounter on a university campus led him to study biomaterials.
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If any of this sounds cool to you, please check out our paper here👉 https://t.co/W5JtueTlbP And feel free to reach out to me about the models if you're thinking about applying them to your own system! [🧵7/7]
science.org
Pf phages and sputum polymers reduce antibiotic diffusion via electrostatic interactions and liquid crystal formation.
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Thanks to my co-first author Qingquan Chen, as well as @bollyky, @ebburgenerMD, @PRSecor, @ASpakowitz, @HeilshornSarah and many others. Love when interdisciplinary work can generate new insights and excited to dig deeper into biophysical mechanisms of antibiotic tolerance![🧵6/7]
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The binding and diffusion parameters can be carried from one model to the next and were used to test the hypothesis that electrostatics governed antibiotic diffusion in sputum. We found that electrostatics alone were insufficient in explaining the hindered diffusion. [🧵5/7]
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3⃣We also derived a set of 3 models that can be extended to any system where binding and diffusion occur simultaneously. These 3 models cover the scenarios of: 1) no binding, 2) binding to 1 other species, and 3) binding to 2 different non-interacting species. [🧵4/7]
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2⃣However, the slower diffusion is not simply a result of electrostatic binding to negatively charged components DNA and phage but also due to liquid crystalline structures formed in the presence of these components [🧵3/7]
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1⃣We show that diffusion of positively charged antibiotics like tobramycin are hindered significantly more when both DNA and filamentous bacteriophages are present in sputum [🧵2/7]
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🚨New paper alert! Happy to share our work on how electrostatic interactions and liquid crystalline structures synergistically promote🦠Pseudomonas antibiotic tolerance [🧵1/7]
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Pseudomonas partners with Pf phage to build biofilms and promote antibiotic tolerance. Here, we explore how. Congrats to Kevin Chen, @cai_pam @PRSecor, @heilshornlab @ASpakowitz @ebburgenerMD and a terrific team
science.org
Pf phages and sputum polymers reduce antibiotic diffusion via electrostatic interactions and liquid crystal formation.
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