Fernández Arias et al. show that plasma p-tau217 concentrations are more strongly associated with cognitive performance in AD than other plasma p-tau biomarkers, and outperform the other biomarkers in predicting memory impairment.

RT @braincomms: @braincomms welcomes applications for the next editor in chief 🤓. Please find further details here .

Spencer et al. investigate the use of intracranial stimulation to improve movement in people with Parkinson's disease. They show that stimulating the globus pallidus internus improves motor function beyond the stimulation period.

Disentangling epilepsy and dementia: more to do, together. New scientific commentary by Arjune Sen

Using multimodal imaging, Tohyama et al. show that individuals with migraine have white matter damage in the trigeminal nerve, which is associated with neuroinflammation and with reduced communication with a key trigeminal sensory nucleus in the brainstem.

Tra et al. propose that the resistance of sensory dorsal root ganglion neurons to ALS pathology may be due to the absence of a typical axon initial segment.

Cortical spreading depolarization is thought to trigger headache through inflammatory signals in the brain/meninges. Using an intact mouse brain model, Kaya et al. explore the mechanisms that may suppress the neuroinflammatory response initiated by CSD.

Ashikawa et al. present a new rat model of acute neuromyelitis optica, characterized by extensive astrocyte loss in the spinal cord, and show that regeneration of astrocytes – driven by FGF8 signalling – contributes to functional recovery.

Silva-Rodríguez et al. show that patients with AD with Lewy body (LB) pathology experience faster cognitive decline and more severe hypometabolism than pts without this pathology. However, LB pathology is not associated with atypical phenotypic features.

Peruzzotti-Jametti et al. examine the remyelination potential of mouse- and human-derived directly induced neural stem cell (iNSC) grafts, and show that iNSCs can differentiate into mature oligodendrocytes and remyelinate axons in demyelinated lesions.

Bevilacqua et al. explore whether a novel brain stimulation method – cortico-cortical paired associative stimulation (ccPAS) – can improve vision in stroke patients with occipital lobe damage.

Seeing the trees in the wood: the importance of co-pathologies in Alzheimer’s disease and dementia with Lewy bodies. New editorial by Rimona S Weil:

Kazazian et al. review the use of neuroimaging in disorders of consciousness, detailing key methods (fMRI, EEG, PET) and imaging paradigms that can be used to improve diagnosis and prognosis.

Parker et al. studied 200 former elite rugby players with brain health concerns in mid-life. While anxiety, depression and memory symptoms were common, performance on objective memory and cognitive tests was similar to that of age-matched controls.

The converging paths to hippocampal sclerosis of ageing: insights from LATE-NC and vascular disease. New scientific commentary by Ryan Coburn and Hugo Botha

Medial temporal lobe structural changes when Down syndrome and Alzheimer’s disease collide. New scientific commentary by Laura Wisse and Renaud La Joie

Benninger & Goldberg argue that early surgery for lesional focal epilepsy should be considered even before the emergence of drug resistance.

Using PET imaging and post-mortem brain tissue from individuals with progressive supranuclear palsy, Wijesinghe et al. find that microglia are the key immune cells driving TSPO PET signal changes.

Proelss et al. describe the mapping of human genital representations by electrical stimulation of somatosensory cortex. Males but not females report genital sensations in response to stimulation of the postcentral gyrus.

Russ et al. review the causes and consequences of fetal malformations of cortical development, and present clinical practice guidelines for their pre- and postnatal management.