Learn more about this pioneering initiative and MJFF's impactful grant funding here: 👉 Chronos-PD Grant Details.(5/5).

💡 The team is making rapid progress, and groundbreaking results are just around the corner—stay tuned for updates! Honored to be the #PI of this transformative program (4/5).

Our work aims to identify plasma-based biomarkers that could predict Parkinson’s disease years before clinical diagnosis. With Chronos-PD, we are paving the way for earlier diagnostics and groundbreaking therapies across multiple diseases (3/5).

🚀 With the support of #MJFF, #Chronos-PD exemplifies this transformative potential by integrating deep longitudinal proteomic profiling with over 100 million proprietary plasma samples linked to real-world data (2/5).

Large-scale proteomics is unlocking in a new era of biomarker discovery and therapeutic target identification. #Chronos offers a unique opportunity: high-temporal-resolution profiling of 100 millions longitudinal plasma samples across pre-clinical phases of any disease (1/5).

RT @Oliver__Hahn: Excited to share our preprint about the spatiotemporal dynamics of mammalian #brain aging. With our new map generated at….

Preprint alert! A must read from Oliver Hahn who generated a spatiotemporal gene expression map of 15 brain regions! .This study shows that the white matter tracts are an early hotspot of brain aging! Many other cool findings to discover here 👇.

Data from NIH-funded studies will have to be shared. This won't be straightforward to implement but that's a huge step for open science 👇.

Altogether, these findings demonstrate the existence of anti-inflammatory exercise factors that are transferrable, target the cerebrovasculature and benefit the brain. Great collaborative work started almost 10 years ago!.

Last but not least, real world data from patients with cognitive impairment who participated in structured exercise for 6 months had higher plasma levels of CLU but also broadly implicate the complement and coagulation cascades in exercise

Intravenously injected CLU binds to brain endothelial cells and reduces neuroinflammatory gene expression in a mouse model of acute brain inflammation and a mouse model of Alzheimer’s disease

Interestingly, plasma proteomics revealed a concerted increase in complement cascade inhibitors including clusterin (CLU)

Runner plasma also counteracts LPS-induced brain inflammation

In this study led by Zurine De Miguel from the @wysscoray lab, we show that ‘runner plasma’, collected from voluntarily running mice and infused into sedentary mice induces neuroplasticity, improves cognition and reduces inflammation

Thrilled to see this paper finally out in @nature. We all know about the overall beneficial effects of exercise, but little is known about the factors and mechanisms that mediate its effect on the brain.

RT @lpachter: It's time to stop making t-SNE & UMAP plots. In a new preprint w/ Tara Chari we show that while they display some correlation….

RT @EGeroscience: @j_n_justice, @blehall and Irene Martinez de Toda will talk about "Involving new blood into #geroscience". Mark your age….

Our new @NatureAging paper is the direct evidence that we should closely look at the main contributors of aging clocks. In this study led by David Furman, CXCL9 was identified as having a key role in age-related chronic inflammation!.

Proteomic aging clocks are very intriguing. Read our latest paper in #AgeingResearchReviews in which we show that the aging clock we previously described is a rich source of viable anti-aging drug targets. Still a lot to understand about aging clocks!.

New research topic in Frontiers in Neuroscience on the links between the blood and brain disorders. Consider submitting a paper! Abstracts are due by May 24 and manuscripts by Nov 23.