Beggs Lab
@beggs_lab
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Cancer Genetics research laboratory at the University of Birmingham UK
Birmingham, England
Joined November 2016
We had a good day - really proud to be part of this important UK and Spanish consortium to futher Bowel Cancer research for the next 5 years! Great team (L-R) of @beggs_lab @JenSeligmann @DrPipDunne @trevoragraham @cruk_nbc @leedham_simon @owen_sansom, Crispin Miller,
Intense but exciting day for the CRC-STARS interview team at CRUK headquarters!
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Congrats to Ollie (not on twitter) part of Gary Middletons group and @beggs_lab !
Oliver Pickles received a Postdoctoral Research Bursary from our Research Careers Committee. Oliver will use patient-derived explants/tumour fragments to assess efficacy of immune checkpoint blockade in #ColorectalCancer liver metastases. [1/2] @unibirmingham | #CRUKFunded
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ONCOLOGISTS - we have an associate prof post available! Work with us in Birmingham and get access to one of the largest Oncology units in the UK More details in my LinkedIn post here - https://t.co/eFYac6FlEl Or job is here: https://t.co/UmZHPPNm26
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Explore alterations in #cancer driver genes in patients with #cholangiocarcinoma with @beggs_lab, Javier Herrero, Ian Tomlinson, Juan Valle, John Primrose & John Bridgewater at #ASCO23: https://t.co/ja7Y2GfrUK
#CRUKFunded
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Sequenced by @beggs_lab - with: 👉 RNA extraction using @Covaris NA extraction 👉 @QIAGENscience DNA and RNA multimodal NGS panel 👉 Custom @uob_bear pipeline based on @nextflowio It’s not easy but we are getting better at sequencing these historical samples
#NGS data from #Bilcap in #ASCO23 ⁉️Higher than expected FGFR2 fusions (24%) Why? 👍🏻High sensitivity of RNA seq 👍🏻Lots of tissue - surgical specimen BUT 👉Maybe FGFR2 fus+ve CCA are “more likely resectable”? 🤔Adjuvant studies feasible? 🔮Must learn natural history of fFGFR2
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BILCAP Sequenced by @beggs_lab - with: 👉 DNA & RNA extraction using @Covaris NA extraction 👉 @QIAGENscience DNA and RNA multimodal NGS panel 👉 Custom @uob_bear pipeline based on @nextflowio It’s not easy but we are getting better at sequencing these historical samples
🔥Impact of genetic alterations in pts with intrahepatic cholangiocarcinoma treated on the BILCAP clinical trial #ASCO2023 🔎RNAseq from 100 pts, may have an impact on frequency of GAs, specifically FGFR2 fusions 👉No impact of FGFR2 or IDH1 👉EGFR ampl. associated with worse OS
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Another @nanopore sequencing blinder from @JoStockton1 in @beggs_lab: Apparently you can't amplify methylated DNA and maintain the methylation - well you can! Top sample - conventional WGA Middle sample - methWGA Bottom sample - original sample
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Many thanks to @The_MRC for funding my Senior Clinical Research Fellowship today funding the use of these👇 organoid models to investigate mechanisms of chemoradiosensitivity as part of the @FoxtrotStudy and STAR-TREC trials - to make therapy better and less toxic for patients!
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Are you a medical oncologist looking for a job? Do you want to work with us here in Birmingham? We have *THREE* associate professor posts available - apply here: https://t.co/7i4BVnDuku
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Molecular characterisation of colorectal cancer related peritoneal metastatic disease. More effective treatments are urgently needed! Great collaborative project at @amsterdamumc @CancerCenterAms @oncodeinstitute @SPeritoneum @kwf_nl #colorectalcancer
https://t.co/Ch6ES9JBqr
nature.com
Nature Communications - Colorectal cancer can lead to the development of peritoneal metastases, which are associated with worse disease outcome. Here, the authors characterize peritoneal metastases...
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New toy to play with @GenomicsB @beggs_lab as we try some @bionanogenomics Saphyr optical genome mapping on blood cancer samples with NHS S&C GMSA @GenomicsEngland - contact us for more details if interested…
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Here’s the latest paper that @beggs_lab has helped with lead by the superstar postdoc (who was a PhD at the time) - @regina_andrijes - finding that a tetraspanin seems to provide a RAS independent mechanism for responsiveness to EGFR therapies - https://t.co/zwdmoPfh18
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Exciting news as the paper on RTF-ExPAR, a novel method of amplifying direct from RNA, in as little as 2 mins has landed on @PNASNews this evening - led by @GiovanniCarterJ @JimTucker_Group and @T_dafforn with help from us @beggs_lab - https://t.co/RH4SaYelDU
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Working with @ferencmueller we @beggs_lab have branched out into 🐟🐟🐟 by making the most complete zebrafish genome assembly that exists currently using @nanopore sequencing - resolving the miR-430 repeat locus that was unresolvable using other long read techniques
Please check out our latest preprint https://t.co/lCctjD5OzB. Work led brilliantly by @HadzhievYavor and @lucy_wheatley. Thanks for great support by @adbeggs @SMBurgessLab contributions by Ledean Cooper @fansalon64 @remosanges @stegustincich Zhelin Chen and Celina Whalley.
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Another recent paper using NGS & CyTOF from @beggs_lab - we showed that pathCR in rectal cancer seems to be associated with: 👉⬆️ mutational load and neoantigens 👉⬆️ CNAs but ⬇️ SV 👉Dense CD8+ infiltration Read here - https://t.co/WW0ViSEXmN
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Congrats to @RobertTyler01 from @beggs_lab who has published this early output on the genomics of liposarcoma from the 100K genomes project, integrating WGS, RNAseq and methylation - https://t.co/JL8iYxSKiN
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Here’s our latest preprint that came out of @TGNieto PhD thesis @beggs_lab . We’ve found that a long non coding RNA may provide a route to development of dysplasia in Barrett’s oesophagus - well done Tom! https://t.co/tpWxOhSIFh
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JOB! There’s not much time left to apply for the Sarcoma Research a fellow job. Do you want to do something different after COVID? We are offering a MD/PhD in sarcoma research backed by a @CRUKresearch funded programme. On calls with renal transplant - https://t.co/muBagQVtLi
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So it’ll probably get lost in all the noise today on Twitter, but here is our preprint on more than *24,000* samples analysed by @nanopore LamPORE technology - both symptomatic and a symptomatic patients - finding > 99.5% sens and spec - https://t.co/tzAnV6t4dh
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Congrats to @sally84hallam from @Beggs_lab who carried out the double whammy of passing her PhD viva with minor corrections AND having a paper from it published in SciRep. But what has she found? (Thread)
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