Simon Leedham
@leedham_simon
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Professor of Molecular Genetics at University of Oxford. Gastroenterologist.
Joined October 2020
So excited to get underway on CRC-STARS - a brilliant collaborative effort to improve therapies for colorectal cancer. Thanks to all the colleagues, patients and funders for helping us get here!.
news.cancerresearchuk.org
The CRC-STARS team will learn more about how bowel cancer behaves so that it can potentially be treated in a more personalised way
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Being forced to read the rantings of a megalomaniac is too much for even a very occasional user of this site. I’m done. See you at @leedham-simon.bsky.social.
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Congrats to the excellent @HollyEggington on completing her DPhil. Now just the MB part needed for the Dr Dr double! Many thanks to @DrPipDunne and @sarah_blagden for examining
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Intense but exciting day for the CRC-STARS interview team at CRUK headquarters!
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Fully deserved. Congrats stuey.
Over the moon to be appointed Professor of Gastrointestinal Biology at Queen Mary University of London. Many thanks to @abobbyandrews ,@trevoragraham , my collaborators and those in my group past and present whose support was everything @QMBCI @QMUL @CRUKresearch.
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RT @DrPipDunne: 🚨RTs please🚨. Apply to join our spatial hackathon, full details below and the call is looking for applicants across a range….
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RT @trevoragraham: Inflammatory bowel disease (#IBD) increases bowel cancer risk: 1/3 of patients with low grade dysplasia (LGD) will get c….
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RT @FrancoiseSHowe: And huge congratulations to @HollyEggington for being the best early career researcher poster prize winner for the mech….
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RT @FrancoiseSHowe: Great flash talk by @HollyEggington @HumanGeneticsOx on the potential of BMP4 activation for colorectal cancer preventi….
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Bioarchiv paper here, This was a fabulous collaboration with @JoshuaABull, @EJ_Mulholland, @Moore_JW_, Helen Byrne and many others.
biorxiv.org
Spatial biology has the potential to unlock information about the disrupted cellular ecosystems that define human disease. Quantitative analysis of spatially-resolved cell interactions allows mapping...
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Through the adaption and application of a range of these maths tools, we demonstrate that immune and stromal cell interactions change with pathological state, as a rectal cancer emerges from a paired benign adenoma.
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Have you ever generated a beautiful spatial biology image but had no idea how to biologically interpret it? So did we! We have spent 2 years working with a wonderful group of mathematicians to develop a suite of spatial descriptors to quantify cell interactions from multiplex IHC
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Pleased to present latest lab preprint showing how pathological disruption of intestinal BMP gradients gives rise to ectopic stem cell niches through stromal remodelling.
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Our new study demonstrated real world difficulties in applying histological stratification tools in colitis-associated dysplasia, which remains very challenging. Congrats to @NadiaNasreddin who coordinated a wonderful group of expert pathologists.
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Immigration of skilled workers supports both the NHS and British science. Both have already been negatively impacted by Brexit. This knee jerk bill will prevent essential recruitment into these professions and further degrades British success stories.
The level of net migration is too high. Today we’re announcing a new plan to reduce immigration and curb the abuse of our visa system. Here is what we're doing 🧵👇
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RT @CRUKresearch: Daniel Royston and Jens Rittscher will refine & validate an #AI-based approach to #EarlyDetection and assessment of myelo….
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RT @christophertape: Very excited to share our new pre-print: ‘A Single-cell Perturbation Landscape of Colonic Stem Cell Polarisation’ led….
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RT @trevoragraham: We see and feel the loss of talented EU students in postgraduate research (including postdocs). The high overseas studen….
theguardian.com
Data shows sharp decline in students from Italy, Germany and France with Brexit seen as primary deterrent
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