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James Profile
James

@basedsystems

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127

@hoxbio

Joined December 2024
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@basedsystems
James
3 days
A larger number of you than expected wanted to access this. We are almost done with a product sprint that will allow open access
@basedsystems
James
14 days
We built an ultra-fast genomics viewer for the browser. Before YouTube, sharing videos online was painful. Files were too large to email, too large to host, formats were not standardized, and each video existed in isolation instead of as part of a wider database. This is the
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@basedsystems
James
3 days
we’ve been working on our own chemistry for full-length RNA capture (released shortly as a long reads service), and it looks unbelievable on TTN
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@basedsystems
James
10 days
when I was like 9 years old this is how I made money. AI taking jobs 😭
@maxbittker
max
11 days
racing Opus 4.6 against 4.5 to max out a Runescape account
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@basedsystems
James
14 days
@basedsystems
James
14 days
@LounsberyScaife We don't have support for methylated reads yet but it would be straightforward to add it. The backend to the viewer is actually a multimodal warehouse we wrote. So, it's fairly arbitrary what features and scale we can support. Below is an example of cDNA reads
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@basedsystems
James
14 days
can handle enormously deep pileups
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@basedsystems
James
14 days
Still very fast with very deep, long reads.
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@basedsystems
James
14 days
We built an ultra-fast genomics viewer for the browser. Before YouTube, sharing videos online was painful. Files were too large to email, too large to host, formats were not standardized, and each video existed in isolation instead of as part of a wider database. This is the
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@basedsystems
James
19 days
the thing I love about my whoop is it’s like “wow you barely slept, you must feel like ass” and it’s like yes actually I do feel like ass thank you very much
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@basedsystems
James
20 days
in Florida our data is disjointed and our search is manual like god intended
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@basedsystems
James
20 days
NO DATA INTEGRATION ALLOWED IN FLORIDA
@j_fishback
James Fishback
20 days
As Governor, I will ban Palantir in Florida.
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@basedsystems
James
26 days
exAI will become gfAI
@elonmusk
Elon Musk
26 days
@AmandaAskell Unfortunately, any given AI company is destined to become the opposite of its name, so Anthropic will, ironically, be Misanthropic
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@basedsystems
James
28 days
this whole process is more scalable than people think
@sytses
Sid Sijbrandij
28 days
I’m going Founder Mode on my cancer. Below is Elliot Hershberg’s article about my cancer journey. It gave language to something I’d been doing instinctively over the past year: managing my health in Founder Mode. Manager mode assumes that existing systems will surface the best
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@basedsystems
James
30 days
I bet this has been horrible for taco bell
@Polymarket
Polymarket
30 days
JUST IN: Weight loss drugs like Ozempic on track to save U.S. airlines more than half a billion dollars in fuel costs this year.
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@tszzl
roon
1 month
@ZeffMax “misconduct” so bad that it required six months and for him to quit and accept a competing offer before he was fired
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@basedsystems
James
1 month
honestly I think one more podcast and our problems are solved
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@basedsystems
James
1 month
no two countries with a shared netflix account have ever gone to war
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@poetengineer__
Kat ⊷ the Poet Engineer
1 month
strata
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@basedsystems
James
1 month
Excited to finally share what we've been working on for the past two years at HoX. HoX is an integrated platform for autonomous life sciences. The goal of our platform is to deliver end-to-end scientific and clinical services at low marginal cost. We hope to be the world’s most
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@basedsystems
James
2 months
looking forward to the 2026 shit show
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