Aina Martínez i Zurita
@am_zurita
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PhD Student at @UCLA, working with @ngarud and @lohmueller • Evolution and story telling • Previously at @MIT & @broadinstitute • Catalana • she/her
Cambridge, Massachussets
Joined February 2011
We also suggest a path forward for correcting for selection on synonymous mutations. (8/8).
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With rampant strong negative selection on all synonymous mutations, DFE inference breaks down. With less pervasive selection, however, inference of the DFE is less biased, suggesting some robustness to some selection on synonymous mutations. (7/n).
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Overall, we found that demography is often mis-inferred when synonymous variants are under selection. However, the effects on inference of the DFE are parameter dependent. (6/n).
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Using simulations (Shoutout to @sticksoftware and @MesserPhilipp for the incredible and beautifully documented resource that is SLiM), we look at how our ability to estimate the DFE of non-synonymous mutations is impacted by selective pressures on��synonymous mutations. (5/n).
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Synonymous sites are used as a putatively neutral reference when inferring the distribution of fitness effects (DFE) of non-synonymous mutations. (4/n).
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Are synonymous mutations truly neutral? Jury is still out, but how would selective pressures on synonymous mutations impact computational methods that rest on the assumption that synonymous variants are neutral? (3/n).
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I am very excited to present the first paper for my PhD, in collaboration with @ChrisKyriazis and under the fearless direction of @lohmueller. (2/n).
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A wild pre-print appears! Come read about how incorrectly assuming that synonymous mutations are neutral impacts our ability to properly infer fitness effects of non-synonymous mutations. (1/n).
biorxiv.org
The distribution of fitness effects (DFE) describes the proportions of new mutations that have different effects on reproductive fitness. Accurate measurements of the DFE are important because the...
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Amb moltes ganes de conèixer als alumnes de l'@IEelviver per parlar de com estudiem l'evolució del nostre microbioma!. Very excited to meet the students from @IEelviver to talk about how we use the microbiome to study evolution! . #100tifiques #11F.
This year's #100tífiques will bring 476 women scientists, including 69 from BIST research centres, into 427 schools (virtually and in-person) across Catalonia. More than 40,000 children are expected to take part! #11F @fundaciorecerca @educaciocat .
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Sometimes, graduate school feels like an unjustifiably and unnecessarily painful endeavor. Other times, I spend until 4am reading fascinating science and can barely believe this is my life. The whiplash is dizzying.
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I think I just changed my mind on Polygenic Risk Scores: even though their predictive power is limited and there are clear equity issues, being able to forecast some amount of disease risk seems obviously useful.
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Apparently it's too much to ask to have an employer that will pay you on the same day every month 🤔.
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My relative asked me if it's true that in America, pills are swallowed "without drinking water" because he'd seen it in a movie.
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Currently wishing people understood the very important difference between "we are all getting COVID" and "we are all getting COVID at the same time".
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We have a union! 🤩.
BREAKING: UC agrees to recognize SRU-UAW in its entirety! This historic victory was brought about by the tireless efforts of thousands of SRs who organized to win a union & a direct response to our massive Strike Authorization Vote. Now let’s win a strong contract for all SRs!
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I'm so proud of my mom :) @szuritamon.
Certain games have an interesting feature of combining randomness into them that may help young students to learn the randomness of evolutionary processes, Silvia Zurita suggests at @EvoKE_BCN21.
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