Alice Sanson
@alice_sanson
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PhD student at University of Regensburg @Agmaternal. Curious about the maternal brain alterations in conditions of neglect
Joined September 2020
Congrats to @DemarchiLuisa for this fantastic work! ✨.
Very happy to share that the last data from my PhD is now available as a preprint! Huge thanks to @OliBosch , @alice_sanson and all my former colleagues for their support throughout this journey.
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RT @SValtcheva: 5 years ago during a midnight confocal session I got intrigued about unknown to me at the time brain area. Today we are exc….
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I’m truly grateful I had the chance to share this work with a fantastic team @DemarchiLuisa @EmmaRocaboy @OliBosch! 🙌🏼 5/5.
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Finally, members of the CRF family showed differential expression in male and female rats. 4/5.
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The CRF-R1 and -R2 modulated #anxiety-like behavior in a sex-dependent manner! CRF acted anxiogenic in male rats only, while UCN3 increased anxiety-like behavior in famale rats, regardless of the reproductive state. #sexdifferences 3/5.
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New paper out and open access in @NeuropharmJ! .I’m happy to share another piece of the puzzle about the role of the CRF and OXT systems in the nucleus accumbens shell (NacSh) in the postpartum period. You can read it here: 🧵1/5
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✨ Stay tuned, more findings about the shell and maternal behavior coming soon!! ✨ (8/8).
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In line witth findings in mice, the NAc shell of female rats receives CRF inputs from the mPFC, BLA, PV, dorsolateral entorhinal and perirhinal cortex, and ventral subiculum (7/8).
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CRF-R2 are mainly expressed in the rostral NAc on MSN, and their expression on GABAergic interneurons increases towards the caudal pole (6/8).
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In lactating rats, CRF-R1 are predominantly expressed on medium-sized spiny neurons (MSN) in the medial NAc, while they are mostly located on GABAergic interneurons in the rostral part of the NAc (5/8).
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CRF induces both oxytocin and dopamine release, while Urocortin3 triggers dopamine release, with a different pattern compared to CRF (4/8).
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Maternal aggression elicits oxytocin release and activates CRF+ cells in the shell (3/8).
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Activation of the CRF receptors (CRF-R) and inhibition of the oxytocin receptor in the NAc shell impair pup defence in lactating rats (2/8).
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‼️Preprint alert‼️. I’m thrilled to share a big part of my PhD project exploring the role of #CRF and #oxytocin in the nucleus accumbens (NAc) shell in #maternal #aggression, now available on @biorxiv_neursci!. Here the link: 🧵(1/8)
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RT @OliBosch: Long story about the nucleus accumbens in short:.- Infusion of CRF, UCN3 or oxytocin antagonist in the shell impaired materna….
biorxiv.org
Maternal aggression is a core feature of rodent maternal behaviour to defend their offspring from potential threats and is modulated by corticotropin-releasing factor (CRF) and oxytocin (OXT) systems...
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RT @bsneuroendo: 📢 NEW quick-read Neuroendocrine Briefing alert!. To bond ❤️ or not to bond💔: Neuroendocrinology might have the answer . Au….
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RT @rohitmenon1986: @laura_stangl_ gives a wonderful talk summarizing her work on the biochemical characterization and function of medial….
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RT @DrPaulaBrunton: Fantastic to see this finally come to fruition! Thanks to my co-editor @ProlactinGuy and all the contributing authors,….
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