Aaron Weiner
@aaiweiner
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Cell and Molecular Biology PhD Candidate in the Vaughan lab at the University of Pennsylvania
Joined June 2012
New research in @CellReports led by #PennVet’s Andrew Vaughan, PhD, and Aaron Weiner, PhD candidate, identifies a factor responsible for improper tissue regrowth after #respiratoryinfection, pointing to a possible therapeutic target. Read More: https://t.co/iYiFeYLBzI
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Absolutely thrilled to share @aaiweiner's thesis work from my lab, out now in @CellReports! In short, loss of the transcription factor p63 increases the ability of basal cells to transdifferentiate into alveolar cells. (1/2)
cell.com
Weiner et al. find that ΔNp63 is required for dysplastic remodeling of the distal lung after severe pulmonary injuries. Without ΔNp63, the basal-like cells responsible for this remodeling either...
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My fiancée @j_macdoug’s favorite gene is Epcam… never heard anything more basic in my whole life
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Excited to share our preprint on microstructured hydrogels for lung alveolar organoids. Great collaboration with @vaughandy @WestPhillyTough @BurdickLab & Ed Morrisey to characterize Matrigel-free iPSC and primary alveolar organoids in vitro & in vivo, 1/2 https://t.co/oBgveY2SN1
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So strange: our lab ordered several dead cats but only ended up with 50mL conical tubes???
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Here's our preprint on human lung progenitor cell orthotopic xenotransplantation. I think this will be useful for a lot of folks. I had hoped for this to be a bit more mature before release but in light of other groups with similiar ideas...
biorxiv.org
Humanized mice possessing human cells, tissues, or organ systems provide an unparalleled platform for preclinical studies in oncology, immunology, and infectious diseases. While the lungs are a vital...
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A perspective on how miserable the US has managed COVID: My visiting scholar @zhao_gan is defending his thesis remotely for his home university in Wuhan. The other defendees in Wuhan are hanging out in a room with 8-10 people, eating food. It’s clearly under control there.
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We are sad to announce the passing of our dear colleague and former IRM Director John Gearhart. John's groundbreaking isolation of human pluripotent stem cells and relentless advocacy for stem cell research funding made him one of the best champions our field could ever have.
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My boss is famous
FWIW, I was briefly on local news today talking a little about COVID-19 and some of the work we're starting... very glitchy but anyway
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Really thrilled Penn Today chose to feature our new paper!
penntoday.upenn.edu
A serious case of the flu can cause lasting damage to the lungs. In a study in mice, researchers found that transplanting cells from the lungs of healthy animals enhanced healing in others that had...
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