Ranabir Chakraborty
@_ranabir
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Cellular neuroscience graduate student at Institut Pasteur. Contact-mediated neuron-microglia interaction in neurodegeneration-neuroinflammation
Paris, France
Joined June 2019
Massive thanks to @Veronicatesta96 , Jara Montero-Munoz, and @ConsiglioLab for a fruitful collaboration. It was amazing working together.
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Happy to share our work (final aspect of my thesis). We tried to understand why neuronal and microglial cells upregulate TNTs in the presence of α-Synuclein aggregates? Turns out inflammation has a major role to play in the process!
biorxiv.org
Tunneling nanotubes (TNTs) enable direct intercellular transfer of macromolecules, organelles, and pathogenic protein aggregates. While α-synuclein (α-Syn) aggregates are known to promote TNT...
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We now have an updated version of this story - new experiments and analysis added!.
biorxiv.org
Tunneling nanotubes (TNTs) play a crucial role in intercellular communication, enabling a dynamic network for the transfer of molecular cargo over long distances between connected cells. Previous...
Delighted to share a second part of my Ph.D. work. As a follow-up of our previous observations, we wanted to understand the reason behind directionality of aggregate transfer between neuronal cells and microglia.
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RT @AleksDeLab: And it's out! The BIC lab presents our new perspective article on "Immune Control of Brain Physiology" - fresh off the pres….
nature.com
Nature Reviews Immunology - The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and...
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RT @midweekwarrior: It's here! I'm recruiting a #postdoc to work with me on an ANR funded project @institutpasteur! Check it out! We're in….
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RT @G_Frasca: Great @BCI_Pasteur retreat in sunny Cap Esterel with amazing science and passionate people 🥳
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Had a great time working with with Philippa on this story, with fantastic support from @ZurzoloLab.
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Consequently, autophagy flux was inhibited in neuronal cells (and not in microglia). We hypothesized that autophagy dysfunction could be one of the reasons for directional aggregate transfer, and it indeed was.
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With the arrival of (twitter-less) Philippa in the lab las summer, we looked into the effects of alpha-Synuclein aggregates on lysosomes, and observed that neuronal lysosomes were more sensitive to aggregates than microglial counterparts!.
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Delighted to share a second part of my Ph.D. work. As a follow-up of our previous observations, we wanted to understand the reason behind directionality of aggregate transfer between neuronal cells and microglia.
biorxiv.org
Tunneling nanotubes (TNTs) represent a major form of intercellular communication, enabling material exchange of different kinds over long distances between the connected cells. Previous investigati...
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RT @myosinactncrazy: Driving autophagy – the role of molecular motors .
journals.biologists.com
Summary: We review the role of molecular motors in autophagic flux, focusing on interactions and post-translational modifications, and we discuss how dysregulation of motor activity in autophagy...
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Highly recommend the @ZurzoloLab. If you are interested, or know someone who might be, feel free to contact the lab, or me directly.
Post-doc position alert! My lab @institutpasteur is hiring post-docs for different projects related to #TNT research in #neurodevelopment, #neurodegeneration, and #fundamental cell biology. If you are looking for one, or know someone, feel free to contact me. Spread the word!
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It was fun to be able to correspond with @biopatrika for this piece. Thank you for reaching out!.
📢 New Author Interview Alert! 📚. 🎙️ Check out the exciting interview with Ranabir Chakraborty (@_ranabir), the first author from the lab of Prof. Chiara Zurzolo at Institut Pasteur @institutpasteur , Paris, France, on #Biopatrika! 🇫🇷🔬.
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The Euroglia conference @gliameeting starts soon in Berlin. If you're attending, come around for my poster on Sunday. I'll give you some gossips on what neuronal and microglial cells are talking about
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So, this happened! @TheScientistLLC covered our work on Tunneling nanotubes connecting neuronal and microglial cells. Online in @cddpress, we show biased directionality of aggregate and mitochondria transfer. Original paper:.
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RT @institutpasteur: 🧠 Identification de tunnels connectant les neurones dans le cerveau en développement ⤵️https:/….
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