Zero-shot antibody design in a 24-well plate @chaidiscovery 1. Researchers have introduced Chai-2, a multimodal generative model that marks a significant leap in de novo antibody and miniprotein design. This platform achieves an impressive 16% hit rate in de novo antibody

It's been a privilege work alongside the most uniquely talented group of individuals I've ever encountered on this breakthrough result @Kevin_E_Wu, @_nathanrollins, @j_boitreaud, @danny_nkjg, @_jackdent , @joshim5, @ZhuoranQ and others. You all made this possible!

How can we use #GenerativeAI for #ProteinDesign? - check out work from our labs @deboramarks and @yaringal https://t.co/mPxqX5TWxd

Want to catch up with the rapid progress in ML for functional protein design? Not sure where to start? Check out our review in Nature Biotech! #ProteinDesign #NatureBiotechnology #Cover

New microscopy technology enables nanoscale imaging of centimetre-scale tissues, making it possible to image the entire expanded mouse brain at cellular and subcellular resolution. #ReviewedPreprint https://t.co/7D3JyPGvWo

New preprint out! Babies are born to breastfeed. While 50% of lactating persons struggle to make enough milk, there are no FDA-approved drugs to enhance lactation. We engineered a long-acting prolactin, Prolactin-XL, to enhance milk production. https://t.co/qv2D2NoU6u 1/14

Announcing popEVE - a deep generative model of the human proteome that reveal over a hundred novel genes involved in rare genetic disorders https://t.co/WjtLLbwhle @Jonnygfrazer @aaronkollasch @H__Spinner @c_sheare @MafaldaFigDias @deboramarks explore at https://t.co/ls3uShlt1a

Excited to debut our work: ML methods that accelerate the development of proteins of interest into full-fledged therapeutics. By making proteins safer, faster, we hope to expand the space of therapies in the clinic!

But if we show all the gene knockouts ordered by genomic position, a curious pattern emerges: CRISPR knockouts look more similar to KOs on the same chrom. arm than to KOs on other arms –producing a striking image of a genome-wide CRISPR map in which genome structure is obvious!

We’ve updated our EVEscape paper with more SARS2 retrospective evaluation and potential use-cases! https://t.co/75UPtmQm7E Collaborators @sarahgurev @NotinPascal @nooryoussef03 @_nathanrollins @sandercbio @yaringal (@OATML_Oxford), @deboramarks, 🧵1/4

Can one anticipate viral evolution enough to support timely intervention? Check out our new preprint on forecasting antibody escape https://t.co/NEi420SlaJ With @sarahgurev @NotinPascal @nooryoussef03 @_nathanrollins @sandercbio @yaringal (@OATML_Oxford), @deboramarks, 🧵1/10

The author recommends some charities with data-supported high impact: https://t.co/JFYXjNRpVY ..a stand-out to me, just $100 de-WORMS 100 children! removes these things!

In wealthy countries with sanitary childbirthing, nutrition, vaccination, child mortality is 1/50th that in poor countries. Our World in Data shows that low income is massively correlated with high child mortality: https://t.co/MO9dKPFC9B

Until recent history, ~50% of children used to die before 5 years old. With modern understanding of sanitation, nutrition, and vaccination, that number is down to 4%. (1) What a pitch for studying biology and medicine! (2) We can and must lower that number!

Our new paper is out in @nchembio where we describe our journey from a #covalent fragment screen to an in vivo active Pin1 inhibitor. https://t.co/DKdvmjYJ6f Below is a musical abstract guest-starring @UriAlonWeizmann and a tweetorial 1/n

By sequencing bat viruses, we could have spotted SARS-CoV-2 predecessors decades before the outbreak. Now 500,000+ SARS-CoV-2 genomes have been sequenced, sampled from humans. We also need that thorough sequencing applied to disease vectors like bats!

Keeping that in mind- SARS-CoV-2 didn't evolve rapidly out of the blue, instead very similar Coronaviruses to SARS-CoV-2 have been gradually evolving for centuries.

Analyzing Coronavirus genomes, Boni et al predict that the viruses that became SARS-CoV-2 branched off from those that became SARS-CoV-1 likely in the middle ages.. and SARS-CoV-2 branched from the nearest bat coronavirus likely 50 years ago. https://t.co/jpNyfhDS3g

Today we report the use of base editing in patient-derived cells and in mice to correct the most common cause of progeria, the devastating rapid aging disease. Progeria is typically caused by a dominant negative C•G-to-T•A point mutation in LMNA. 1/11 https://t.co/O7dkEYpndg

1/n I'm excited to share our preprint *Large-scale clinical interpretation of genetic variants using evolutionary data and deep learning* https://t.co/NrbcuUPbHV from a great collab with @NotinPascal @MafaldaFigDias @AidanNGomez @kpgbrock @yaringal (@OATML_Oxford) @deboramarks 🧵