Journal of Clinical Neuroscience
@_jocn
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Peer-reviewed articles with an international perspective pertaining to the clinical care of patients with disorders of the central and peripheral nervous system
https://www.linkedin.com/compa
Joined April 2023
New issue of Journal of Clinical Neuroscience is live! 🔬🧠 Dive into fresh reviews + original research across neuroimaging, stroke, skull base, epilepsy, spine & more. 👉 https://t.co/UybJmjBTgn
#JOCN #Neurosurgery #Neurology #Neuroimaging #MedTwitter #Oncology #Neuroscience
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🧵1/ 🚨 New study drop! We're excited to share our work comparing reduced-dose ticagrelor, full-dose ticagrelor, and clopidogrel for secondary prevention after acute stroke/TIA. Big thanks to @Harsh_Desai_1, Elena Badillo Goicoechea, and the entire team! https://t.co/irsKCOGHbh
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🪄📕🧠Seeing the world shrink, stretch, distort — yet knowing it isn’t real. This striking case of Alice in Wonderland Syndrome from right parieto-occipital encephalitis shows how one brain region can warp perception. Symptoms reversed with methylpred. Read the full story:
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🧠🔬 New radiomorphometric roadmap for safer ETV from Rincon-Arias et al.!! This study maps a practical “vascular safe zone” for endoscopic third ventriculostomy using pre-op MRI: • In 71.2% of adults, the basilar artery complex sits in the posterior half of the
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📊 This systematic review and meta-analysis examines the role of endoscopic third ventriculostomy (ETV) in Chiari Malformation Type I (CM-I) — providing updated pooled evidence on safety, efficacy, and outcomes across 100 patients. Results show high success and symptom
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New blog: Fresh dueling guidelines about post-arrest care from the AHA & ESICM 💔 BP & O2 targets 💔 Who needs emergent cath? 💔 pan-CT scans 💔 temp targets 💔 neuroprognostication Which guideline do I love? 😍 You'll have to read the post to see https://t.co/pvURD9zg53
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✨ New in Journal of Clinical Neuroscience! A systematic review + meta-analysis of Epilepsy with Eyelid Myoclonia (EEM) reveals: 🔹 69% female predominance 🔹 Photosensitivity in 76% 🔹 Drug resistance in 32% Refining diagnosis, treatment, and understanding of this rare epilepsy
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Let's try something new! 🧠📓NotebookLM used to create a podcast for an article: Prognostic value of procalcitonin and IL-6 with a composite model in moderate–severe TBI. 🔗 https://t.co/b8IEzYOBIq
https://t.co/MX5Bsonzjg
notebooklm.google.com
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6️⃣ Citation: Li X-M, Liu Z-W, Liu W-Y, Su G-J, Huang X-J. Prognostic value of procalcitonin and IL-6 with a composite model in moderate-severe TBI. J Clin Neurosci. 2025;140:111516. 🔗 https://t.co/b8IEzYOBIq
#NeuroTrauma #Biomarkers #TBIResearch #CriticalCare #Inflammation
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5️⃣ Takeaway: IL-6 and PCT are promising inflammatory biomarkers for risk stratification in TBI. A multimodal predictive model may guide early intervention and rehabilitation planning.
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4️⃣ Predictive accuracy: 📊 AUC values IL-6: 0.716 PCT: 0.709 Composite model: 0.917 🔥 ➡️ Combining biomarkers with clinical parameters markedly improved prognostic discrimination.
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3️⃣ Key results: 💥 Poor-prognosis patients had: Higher IL-6 (p = 0.001) Higher PCT (p < 0.001) Lower hemoglobin & albumin Multivariate regression identified 6 independent predictors of 6-month GOS: Hb, Alb, IL-6, PCT, GCS, & Cr
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2️⃣ Study design: 🔹 122 patients with moderate–severe TBI (GCS 3–12) 🔹 Retrospective cohort, 2019–2024 🔹 Biomarkers: IL-6 & Procalcitonin (PCT) measured at admission 🔹 6-month outcomes assessed by Glasgow Outcome Score (GOS)
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1️⃣ Why it matters: After TBI, secondary inflammation drives neuronal injury and long-term deficits. Identifying biomarkers that capture this cascade could refine prognostic modeling and personalize care.
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🧵 Prognostic Value of IL-6 & Procalcitonin in Moderate–Severe TBI New study in Journal of Clinical Neuroscience explores how inflammatory biomarkers can help predict outcomes after traumatic brain injury. 🔗 https://t.co/b8IEzYOBIq
#NeuroTwitter #TBI #NeurocriticalCare
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Post-stroke UTI prevention that works 👉 A nurse-led bladder-management protocol cut 30-day UTIs 9.0% → 5.6%; better compliance = fewer infections (and LOS 18 vs 4 days). https://t.co/1UtAxI7Db9
#Stroke #QI #Nursing #PatientSafety #CAUTI #NeuroTwitter #JOCN
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🇦🇷 Proud to share my first project as a medical student, from idea to publication — is now out in @_jocn! We surveyed 317 Argentine med students to uncover how much neurosurgical education exposure they actually get… and the results were alarming. 🧠👇
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🧠✨ Bottom line: For patients with incidental UIAs, perioperative rupture risk is very low. Meticulous hemodynamic management keeps them safe under GA. #NeuroTwitter #Stroke #Aneurysm #Anesthesia #NeuroSurgery #MedTwitter #CriticalCare #PatientSafety
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💡 Key takeaway: General anesthesia is extremely safe for UIA patients having non-aneurysm surgery. ✅ Vigilant blood pressure control ✅ Individualized risk assessment ❌ No evidence supporting prophylactic aneurysm treatment
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👇🔗 https://t.co/ffjzAy42JE 🧵 📊 21 studies, 627 patients Only 1 perioperative rupture (0.16%) 0 rupture-related deaths Most aneurysms: <7 mm, anterior circulation No specific anesthetic technique ↑ risk
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