
Ellis Chika
@_ecologos
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NIHR Academic Clinical Fellow @QMULPsychiatry | brain imaging researcher @MRC_LMS @ImperialMed @KingsIoPPN | Trainee Psychiatrist @NHS_ELFT
Joined May 2020
I'm pleased to share our review of the synaptic hypothesis of schizophrenia, out now in @molpsychiatry, with Oliver Howes,.@MRC_LMS @KingsIoPPN @QMUL_WIPH.We reflect on >4 decades of evidence, and use this to propose an updated synaptic hypothesis.
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RT @sameerjauhar: Out in Translational Psychiatry , we examine the relationship between 2 of the major players thou….
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RT @VernonLab_KCL: Curious about hiPSC to study psychiatric disorders? Check our consensus paper from the ECNP iPS….
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Human iPSC-derived neurons show lower SV2 and synapsin I puncta density, vesicle release, PSD-95 protein levels and dendritic spine density in schizophrenia, and elevated, complement-dependent elimination of synaptic structures. Key work by @SellgrenLab ➡️
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Post-mortem studies of schizophrenia show lower levels of markers of both pre- and post-synaptic elements in patients, particularly affecting cortical brain regions. See key meta-analysis of pre-synaptic markers by @eosimo.
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