This is what an associate professor looks like 😊

New paper from our PRISM centre led by Martin Grønbæk-Thygesen in @rasmushartmannp lab: Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants https://t.co/jPj64f274j

Our newest paper describes how one can combine multiplexed assays and a global multi-mutant analysis to find variants that stabilize designed proteins across different backgrounds Led by Nic Daffern in the Whitehead lab and @kristofferenoee from our side https://t.co/wKmZEvyidV

New work led by @s_gersing in @rasmushartmannp lab describes a multiplexed assay for variant effects on protein abundance for glucokinase, that together with her earlier work on GCK activity helps explain mechanisms for GCK gain & loss of function variants https://t.co/z4G4t9pV8X

Interest in predicting absolute stabilities of a protein folding? In our new work we show how a generative model for protein sequence can be used to predict absolute protein stability! https://t.co/euGayOZ9de Code: https://t.co/Xr9nNoxzuc Colab:

It`s #EndometriosisAwarenessMonth and I find it terrible how many women are told that the symptoms "are all in their head". So often women are not taken seriously. Happy to see more women speaking up & improved patient advocacy. Fun Fact: my chest tattoo is a large uterus. 💐🫶

Great explanation by @_amelie_rocks on why we use stability predictions and evolutionary sequence analysis to identify pathogenic variants. Her lab performs high-throughput assays on protein variants to develop and improve such prediction models for variant consequences. #ABLS24

What a blast - 3 training sessions & a spatial biology @VIBLifeSciences community meeting as prelude to #ABLS24. A big thank you to our excellent trainers @AmelieStein, Aleksandra Panfilova, @Pathmanaban_, @janani_hex & Peter Škrinjar! Thanks @VIBConferences to host us yesterday!

It’s #InternationalWomensDay and I took my toddler to fringes of a conference. Perhaps modelling that you can be a mom and a scientist 👩‍🔬 instead of the usual proteins. Though in fairness it’s a total coincidence, I have taken her to conferences on other dates too 😀

@jasperzuallaert @VIBConferences @janani_hex Last talk in which @sokrypton walks us through what (some of the commonly used) protein language models really learn - and what they’re still missing 👏 #abls24 @VIBConferences

@jasperzuallaert @VIBConferences We recharged ☕️ 🍪 🍎 and now @janani_hex is sharing new developments and challenges within protein-ligand interaction modelling 👏 #abls24 @VIBConferences

@jasperzuallaert telling us about the importance of experimental biases making their way into ML models, in this case PTM mass spec data 👏 #abls24 @VIBConferences

Next was Gun Woo Byeon talking about encoding two proteins on one nucleotide sequence, inspired by viral genomes 🧬 🦠

Now @befcorreia talks about the 🐘 in the room (of protein design) - and successes from small binders to large solubilised proteins 👏 #ABLS24 @VIBConferences

Last session opens with @ferruz_noelia showing cool new models to capture proteins, including validation experiments 🧪 and approaches to translate between chemistry and biology 👏 #ABLS24 @VIBConferences

Glad to be part of this cool @VIBConferences meeting new colleagues and old friends 😊 🧬 💻

Workshop today, meeting starts tomorrow - looking forward!

#Bioinformatics in life sciences, this hot topic will be explored at #ABLS24. Check out our sneak peek with: 🖥️ Alex Botzki, head of @VIBTechTraining & OC member 🖥️ Amelie Stein (@_amelie_rocks), Assoc Prof @UCPH_Research & invited speaker Read more here👉

🥳 The paper on using AF2 for protein interaction interface discovery has been published at Molecular Systems Biology! Congratulations to all the authors! Have a look 👉

Interested in learning about latest exiting protein design development? Apply for a travel grant and join us to listen to @sokrypton @befcorreia and @ferruz_noelia. Or learn to predict the effect of mutations on proteins with @_amelie_rocks!

We look forward to welcoming our #TWIN2PIPSA collaborators in Copenhagen 🇩🇰 next week for our first workshop If you're local, you are welcome to come and listen to the presentations by colleagues from @UCPH_Research. See programme for the talks below.