Thrilled to see our study ‘Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales’ published @NatureComms, @LSTMnews, @MLW_Programme, #AMR. 🧵👇 https://t.co/w4GyLTQ9aC

In @JournalSpectrum, researchers present an optimized, rapid and cost-effective approach for the targeted surveillance of ESBL-producing E. coli in human stool. Read the article: https://t.co/8X1DeEGM7a

Great collaboration between @LSTMnews, @MLW_Programme, @UQ_News, @LabSchembri, @NottmTrentUni, @LivUni, @univofstandrews

We highlight the continuing challenges of inferring antimicrobial resistance from sequence data and our study suggests that chloramphenicol could be reintroduced as a reserve agent for critically ill patients with ESBL-E infections in Malawi and similar settings.

and association with globally dominant MDR lineages of E. coli is a likely driver explaining the high proportion of chloramphenicol-susceptible isolates.

We found that chloramphenicol re-emergence was caused by stable truncations of resistance genes by insertion sequences. These truncations are stable and widespread, ...

However, many phenotypically susceptible isolates had a genotype indicative of resistance and carried chloramphenicol acetyltransferase genes. We used a combination of functional assays, experimental evolution and genomics to investigate these genotype-phenotype mismatches.

Could chloramphenicol play a role again in the treatment of MDR Gram-negative infections?Susceptibility to chloramphenicol in E. coli and Klebsiella spp. has re-emerged in Malawi, where its use had been discontinued since 2004, raising the possibility of its reintroduction.

You are looking for a PostDoc position or know someone who is? We are looking for someone to join our team at @ETH_en Zürich for a project on phage-host interactions of Pseudomonas aeruginosa 🦠🧬👇🏼

💡The Embassy’s Science and Innovation Team is looking for an #intern! If you are a recent #graduate and interested in research, science policy, startups, #entrepreneurship and #innovation ecosystems, check out the below link and apply by 22 July 2024 👇 https://t.co/76h8cEFrTB

Our MRes in Tropical Health and Infectious Disease Research will help you gain a fully immersive experience of what it means to undertake scientific research alongside world-leading experts. Learn more: https://t.co/MfRYWLpOXo

First preprint of the PhD work by the brilliant @SarahGallichan3 Optimising the microbiology workflows for the recovery of ESBL- E. coli for genomic epidemiology and transmission modelling.

Delighted that our case study investigating piperacillin/tazobactam resistance evolution in a clinical E. coli strain is now available to read on Medrxiv. A big collaborative effort from the wonderful scientists and clinicians involved 🧫 🦠 https://t.co/FExd2qTQ8o

Our fully-funded, four-year MRC Doctoral Training Partnership (DTP) and iCASE studentships, are now open to applicants for an October 2024 start. The deadline for initial applications is Sunday 21 January 2024. Find out more and apply online: https://t.co/wqJr4zWEMy

Just out - more than yet-another-1000-Klebsi-genomes; discussing data and implications with clinicians at Queen Elizabeth and colleagues at MLW makes it one of the most exciting projects for me in years, and hopefully an interesting first output to read😊

Apply now There's still time! Applications are open for all MSc courses, but spots are filling up fast. Limited availability on certain courses. International applications accepted until July 24, 2023, and UK students have until August 31. Don't miss out! https://t.co/joowKE1nXD

Interested in helminths, extracellular vesicles, miRNAs and cell biology? Join my lab @SwissTPH for a fun MSc project or internship in 2023!

Fantastic #AMR journal club @LSTMnews just now. Superbly organised by @_FEGraf & @DaireCantillon who may need to order more pizza for the next one. Thanks for the presentation Joe Lewis

We are looking to hire a Post-Doctoral Bacteriologist for 3 years to work on our @iiconNW funded antimicrobial discovery project. It is at the interface between academia and industry. Closing date 26th August.

#LSTM’s ‘AMR in Microbiology’ journal club led by @_FEGraf and @DaireCantillon delved into the #evolution of #AMR in #biofilms this week! The club are looking forward to welcoming more staff and students in the upcoming sessions 🧫🔬🧬🥼🧪