Zesuliwe Jule
@Zesuliwe_Jule
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Research Laboratory Technologist and PhD candidate at Africa Health Research Institute @sigallab
Durban, South Africa
Joined April 2011
We have been telling Sundowns they must learn to respect Keizer chiefs✌️✌️✌️✌️👌👌 Amakhosi for life, next is that old bones called Pirates, they must just send us to EUFA once🤔🤔 Coach Nabi is dishing up now 🥳🥳🥳 #NedbankCup2025
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Therefore, people with severe Covid-19 made strong neutralizing antibody responses after infection. But people with non-severe disease could make comparable responses, with similar proteomic profiles. If we learn what makes for a strong response, we might be able to harness it.
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Using HSPA8 levels, we could reasonably predict at infection who would make a strong neutralizing antibody response at convalescence:
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We measured people's neutralizing antibodies post-infection. We determined whether they had severe vs non-severe disease by whether they needed supplemental oxygen. The high neutralizer group included people on supplemental oxygen, but also some with non-severe disease
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Differentially expressed proteins in high vs low neutralizers included those involved in SARS-CoV-2 infection, including furin (viral fusion), and HSPA8, (clathrin-mediated endocytosis). Furin was common to the neutralization and disease severity responses (in green below)
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I want to thank the lead author @Afrah_Khairalla, @Zesuliwe_Jule, Alice Piller, @KajalReedoy, @YashiG24, @farinakarim, @KhadijaKhan24, and our collaborators for the terrific effort. It would not be possible without the Gates Foundation Global Health Discovery Collaboratory
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And that's a wrap! ✅ It's been an incredible 2 days of new ideas & collaborations at #SACovidWorkshop2024 The meeting gathered researchers from different fields whose collective expertise &close collaborative networks are essential to preparing for &addressing the next pandemic
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The 2nd South African Workshop on SARS-CoV-2 & Emerging & Re-emerging Infections is underway! The meeting, hosted by AHRI, brings together researchers from 🇿🇦 & regionally who're working on pandemic viruses & viruses with pandemic potential #SACovidWorkshop2024
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We have a new study of SARS-CoV-2 evolution in an advanced HIV disease immunosuppressed person: https://t.co/NzUk2sKCnj We found a microcosm of SARS-CoV-2 variants - viral strains independently evolving to escape antibodies with one sweeping away the other - in one person.
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“Never say die attitude. It’s something that we’ve always had when our back‘s up against the wall.”-Faf de Klerk
'This win represents unity. There's a lot of that lacking in our country. Seeing the videos of people from all backgrounds coming together to support one goal. If we can help each other out, it should be a better country and a better world.' Inspirational from @fafdeklerk
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Our preprint on BA.2.86 live virus isolation, evolution, escape from neutralizing antibodies and virology is now on medRxiv: https://t.co/cyFjiXy4AD
medrxiv.org
Omicron BA.2.86 subvariant differs from Omicron BA.2 as well as recently circulating variants by over 30 mutations in the spike protein alone. Here we report on the first isolation of the live...
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The long time this subvariant spent gaining mutations without spreading is likely because it was either a long infection in someone immunosuppressed or in an animal reservoir. We've seen these kinds of infections before: https://t.co/IkjeWs3xfI
medrxiv.org
To design effective vaccines and other immune interventions against a pathogen, it is necessary to know which aspect of immunity associates with protection. We investigated whether neutralizing...
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I would like to thank @KhadijaKhan24, @richardneher, the folks at the South African NICD, @Tuliodna and the great team who made this study happen.
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#capitec bahlali anivukeni, sinenkinga we got paid but our balances are saying otherwise
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