Youjia Zhong
@YoujiaZhong
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Paediatrician. Allergist. Clinical immunologist. Vaccine scientist.
Singapore
Joined November 2020
If interest to enroll your child (2-17yo, single shot), please contact Ms Ling Qian Hui at 9777 3428.
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The TV003 tetravalent live attenuated vaccine is finally in phase III trials in children! Excited to be part of it, and looking forward to the results 🤓
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Lower respiratory tract infections until 18m of age with Nirsevimab - driven mainly by reduction in RSV and parainfluenza 1-4 but not hMPV. No signal of replacement with non-RSV respiratory viruses.
academic.oup.com
This analysis of lower respiratory tract infections showed that nirsevimab prophylaxis led to lower incidences of respiratory syncytial virus infections ov
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Cancer patients with B cell malignancies and differential expression of CD24, CDK14 and PLEKHG1 have highest risk of breakthrough infections after SARS-CoV2 vaccination .Thank you @kuanrongchan @sundar__raghav for the collaboration! 😎.
nature.com
npj Vaccines - Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination
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RSV reinfection rate decreases by 70% for (only) the first 6 months after an infection
academic.oup.com
Abstract. This study aimed to quantify the effect of age, time since last infection, and infection history on the rate of respiratory syncytial virus infec
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8.6% of children worldwide have a lower respiratory tract infection associated with RSV before 24 months of age
academic.oup.com
In a prospective, observational cohort study conducted in 8 countries across diverse settings, we found that RSV-LRTI burden is substantial during the firs
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Can mucosal immunity ever be durable? Or is durable immunity to viral disease only ever limited to viruses with obligate viremic spread?
journals.plos.org
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RT @ESIDsociety: Get ready to submit your case reports and research papers in the new Journal of Human Immunity! Meet the amazing group of….
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Consider “transcriptotype” to bridge the gap between genotype and phenotype, as cells can randomly and stably commit to gene expression from a single allele. This explains some of the incomplete penetrance in inborn errors of immunity
nature.com
Nature - Somatically determined preferential allelic expression of select genes that when mutated cause inborn errors of immunity corresponds with disease phenotypes, suggesting that the penetrance...
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Both SARS-CoV2 vaccination and infection do not results in long lived plasma cells in the bone marrow 🤯 very strange!
nature.com
Nature Medicine - The rapid waning of SARS-CoV-2-specific serum antibodies observed after immunization with COVID-19 mRNA vaccines may be accounted for by the absence of long-lived plasma cells in...
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RT @EngEongOoi: Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans | Na….
nature.com
Nature Microbiology - The authors demonstrate the effectiveness of T cells in controlling acute viral infections, without neutralizing antibodies, by conducting an Orthoflavivirus vaccination and...
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Senescent T cells and CMV associated T cells associated with arterial stiffness and cardiovascular disease!
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Our data shows that immunocompromised children need SARS-CoV-2 boosters every 6-12 monthly
frontiersin.org
BackgroundIn endemic COVID-19, immunocompromised children are vulnerable until vaccinated but the optimal primary vaccination regime and need for booster dos...
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RT @EngEongOoi: ‘Safety signal’ in Moderna’s RSV vaccine studies halts trials of other vaccines for childhood killer | Science | AAAS https….
science.org
Company found signs its shots made some infected kids sicker than expected, casting a new shadow over the previously troubled RSV vaccine field
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RSV vaccines highly effective against hospitalisation and ED encounters for older adults. Hopefully coming to children soon!
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WFH in Nature! In an RCT, hybrid WFH improved retention without damaging performance. Perceptions about WFH improved after experimentation. The power of a well conducted experiment! 😎
nature.com
Nature - A trial investigating the effects of a hybrid working schedule in a Chinese technology firm in 2021–2022 shows that working from home two days a week improved job satisfaction,...
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Financial incentives works for Singaporeans, grad students, and obese teenagers 🤗.
In adolescents with severe obesity, adding financial incentives to meal replacement therapy resulted in greater reduction in BMI and total body fat without increased unhealthy weight-control behaviors.
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Class II HLA explains up to 10% variance of antibody responses in African infant cohorts for pertussis, diphtheria and hep B vaccines!
nature.com
Nature Medicine - Genome-wide analyses of vaccine antibody responses in 2,499 infants from Uganda, South Africa and Burkina Faso identify associations between specific HLA genes and response to...
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