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Xinjun Zhang Profile
Xinjun Zhang

@Xinjun90

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Assistant Professor at the University of Michigan. Popgen/Evolgen, archaic humans, machine learning etc. @zhanglabpopgen.bsky.social

Ann Arbor, MI
Joined February 2016
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@Xinjun90
Xinjun Zhang
2 months
Super excited to share my latest preprint with @lohmueller and Sriram Sankararaman! Here we leverage the unique signature that recessive deleterious variants can lead to an increase in archaic ancestry to tackle a classic question - the dominance distribution on the human genome.
@biorxiv_evobio
bioRxiv Evobio
2 months
Neanderthal introgressed ancestry reveals human genomic regions enriched with recessive deleterious mutations #biorxiv_evobio.
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@Xinjun90
Xinjun Zhang
14 days
RT @biorxiv_evobio: A global map for introgressed structural variation and selection in humans #biorxiv_evobio.
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@Xinjun90
Xinjun Zhang
21 days
RT @vagheesh: Incredible! Dragon man is a Denisovan. Major congratulations Qiaomei Fu.
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@Xinjun90
Xinjun Zhang
21 days
RT @vagheesh: Based on the new DNA evidence now from Harbin, as well as Xiahe, it's now almost certain that the samples in the yellow box a….
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@Xinjun90
Xinjun Zhang
29 days
Very glad this paper is finally out!.
@TessaFerrari
Tessa Ferrari 🏳️‍🌈
30 days
Final version of our paper on scaling in SLiM now published in @GenomeBiolEvol !. We’ve added some new results comparing coalescence, linkage disequilibrium, and background selection in various scaled simulations. @Jazlyn_Mooney @Xinjun90. Read it here:
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@Xinjun90
Xinjun Zhang
29 days
RT @TessaFerrari: Final version of our paper on scaling in SLiM now published in @GenomeBiolEvol !. We’ve added some new results comparing….
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@Xinjun90
Xinjun Zhang
1 month
RT @yanivbrandvain: **10th Midwest PopGen Conference** .Location: UMN Twin Cities, .Date: Aug 21–22! .Events: Talks, Posters, dinner + MN….
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@Xinjun90
Xinjun Zhang
2 months
n/n This was the last project I started during my postdoc, and finally completed with tremendous help from my postdoc mentors Kirk and Sriram, two UMich biostats MS students (Jiongxuan Yang and Lingxuan Zhu), and many colleagues and friends in MI and CA. Can't thank them enough!.
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@Xinjun90
Xinjun Zhang
2 months
6/n Overall, we show that recessive deleterious mutations not only exist on the human genome, but also are not uniformly distributed and are mostly found in regions regulating metabolism and immune functions (signal regions include HLA).
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@Xinjun90
Xinjun Zhang
2 months
We further investigated the biology of such regions and show they are 1) depleted of haploinsufficient genes, 2) depleted of long ROHs, 3) enriched with UKBB variants with evidence of fitting non-additive model, 4) experienced weaker BGS, and 5) more tolerant to LOF mutations.
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@Xinjun90
Xinjun Zhang
2 months
4/n we then applied the model to 7 non-African pops in 1KG, and detected that approx. 3-9% of the human genome is enriched with recessive deleterious mutation! This is important because previously, dominance is very understudied in humans due to many constraints with methodology.
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@Xinjun90
Xinjun Zhang
2 months
3/n the ML model shows decent power and robustness at finding genomic regions enriched with recessive (or close to fully recessive, such as h<0.1) deleterious mutations at 1MB-scale resolution, with exceptional accuracy in exon-dense regions.
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@Xinjun90
Xinjun Zhang
2 months
2/n we developed an ML approach using archaic ancestry as one of the key features and trained ML classifiers with simulations using fully recessive vs fully additive deleterious mutations. After a rigorous performance comparison and feature selection, we picked a winner ML model.
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@Xinjun90
Xinjun Zhang
2 months
1/n This is a spin-off of some earlier papers showing that recessive deleterious muts can confound adaptive introgression due to heterosis. And we ask a reverse-engineering Q: given the archaic ancestry map, can we infer if any genomic region is enriched with recessive mutations?.
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@Xinjun90
Xinjun Zhang
2 months
RT @jyang1981: This study shows that lowland individuals living at high altitude exhibit accelerated DNA methylation age. .
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@Xinjun90
Xinjun Zhang
3 months
Amazing achievement especially given this rough year! Congratulations Tessa!!!!.
@TessaFerrari
Tessa Ferrari 🏳️‍🌈
3 months
Received an Honorable Mention for my NSF GRFP proposal! It was very competitive year due to funding (< half the usual number of awards) so I’m very happy for an HM. Thanks to my mentors @Jazlyn_Mooney Arun Durvasula & @Xinjun90 for their support & LORs!.Congrats to the awardees🎉.
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@Xinjun90
Xinjun Zhang
5 months
RT @pastramimachine: Really excited to share our new preprint led by @ramencult on a novel signature of selection in georeferenced genotype….
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@Xinjun90
Xinjun Zhang
5 months
RT @biorxiv_genetic: The distribution of highly deleterious variants across human ancestry groups #biorxiv_genetic.
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@Xinjun90
Xinjun Zhang
6 months
RT @hjpimentel: I'm breaking my Twitter boycott for the greater good. We have a school-wide search for an open rank faculty as mentor prof….
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@Xinjun90
Xinjun Zhang
6 months
RT @MKuhlwilm: New paper from the lab just out before New Years! Revisiting adaptive introgression at the HLA genes in Lithuanian genomes w….
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