Wilson Lab
@WilsonLabCITIID
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We are a molecular virology lab led by @samjwilsonphd. ISGs and viruses (SARS-CoV-2, HIV-1, IAVs). https://t.co/Qyk3CTPkHm
Cambridge, England
Joined January 2017
New @wilsonlabcvr paper. Our work, led by @virologist_atu, showing that the prenylated variant of OAS1 can sense SARS-CoV-2 and protect against severe #COVID19 is out in Science:. #CVRCovidResponse.🧵 (with some new bits).
science.org
A component of the human interferon system that activates SARS-CoV-2 cellular defenses appears to be defective in a large proportion of humans.
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RT @EllenFoxman: Our new paper @JExpMed - Nasal viruses & bacteria are very common in children (90% of symptomatic and ~50% of asymptomatic….
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RT @kennethbaillie: I always say jobs in my lab are great opportunities but this one really is. The last incumbent published 3 1st-author @….
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RT @Lab_Rihn_th: đź””'Tis the season. to apply for a new job?! My group @MedCambridge is recruiting for 2 posts:. Postdoc: .
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RT @sci_questions: 🚨Are you attending #ASV2024? Don’t forget the satellite symposium on Bat Virology and Disease Ecology! More details comi….
asv.org
“+I5:I23+I5:I25Mastering the host: Rotavirus manipulation of the translation machinery” “From Cells to Spillover: Unraveling the Tropism and Pathogenesis of Paramyxoviruses” “Uncovering novel...
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RT @Paleovirologist: A lovely piece of work that places interferon-mediated antiviral immunity to betacoronaviruses into evolutionary & eco….
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RT @LongDesertTrain: Really interesting thread and paper about an anti-coronavirus gene in humans that bats lost millions of years ago, whi….
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RT @SpyrosLytras: 🚨New paper alert! and it's one I'm really excited for! Resurrection of OAS1 from the ancestor of modern horseshoe bats bl….
journals.plos.org
The human OAS1 protein restricts SARS-CoV-2 replication, but the horseshoe bat OAS1 has lost this ability. This study reconstructs the functional 60-million-year-old OAS1 protein ancestral to all...
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Thanks to all the authors and the MRC/UKRI for funding this work.
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This study builds on our previous work demonstrating human prenylated OAS1 (p46) inhibits SARS-CoV-2 whereas the nonprenylated (p42) form does not. The nonprenylated human OAS1 p42 is not functionally analogous to nonprenylated horseshoe bat OAS1.
science.org
A component of the human interferon system that activates SARS-CoV-2 cellular defenses appears to be defective in a large proportion of humans.
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The paper is explained in this video from @SpyrosLytras .
🎥 WATCH | Resurrecting an ancient bat defence against SARS-related coronaviruses - @PLOSBiology. @SpyrosLytras & colleagues predicted and reconstructed the ancient horseshoe bat OAS1 protein, showing it blocks #SARSCoV2 replication.
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New WilsonLabCITIID publication led by @SpyrosLytras where we reconstructed an ancient OAS1 from the ancestor of modern horseshoe bats and demonstrate it possessed anti-SARS-CoV-2 activity.
journals.plos.org
The human OAS1 protein restricts SARS-CoV-2 replication, but the horseshoe bat OAS1 has lost this ability. This study reconstructs the functional 60-million-year-old OAS1 protein ancestral to all...
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RT @Lab_Rihn_th: One thing the pandemic forever changed for me was my perspective on sharing biomaterials (tools and reagents) from publica….
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RT @EvirTeam: Join our EVIR team in the fight against the Crimean-Congo hemorrhagic fever! We're looking for a Research Assistant to work o….
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RT @WilsonLabCITIID: Please RT. Are you interested in how viruses emerge in humans? We're looking for a postdoctoral investigator to join u….
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We'll be invested in supporting your career and development. If you'd like more info, contact @samjwilsonphd, or read our recent papers:.
science.org
A component of the human interferon system that activates SARS-CoV-2 cellular defenses appears to be defective in a large proportion of humans.
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Please RT. Are you interested in how viruses emerge in humans? We're looking for a postdoctoral investigator to join us and lead exciting projects investigating innate immune barriers to the emergence and pathogenesis of viruses. Deadline Oct 1st 2023
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RT @fodorlab: 📢 Exciting job opportunity! 📢. A postdoc position is available in our lab at @Dunn_School @UniofOxford to study influenza vi….
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RT @SpyrosLytras: ✨New title unlocked!!✨ Finally a Dr! Big thanks to @katrina_lythgoe and @rbiek for a great viva and ofc to my wonderful s….
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RT @RegGenomics: Join us! A postdoc position between my lab and @QuezadaLab has become available at @uclcancer in London. Please help us ch….
ucl.ac.uk
UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).
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