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Thank you, @LisaPetsinis —your thoughtful words mean a great deal. We're advocating for informed consent that actually informs, and for imaging protocols that reflect the enduring presence of contrast agents. Change begins with candor. More to come. #MRI #Gadolinium.

RT @Lambertdebb: I am curious, why the March 14, 2025 FDA updates for Gadolinium-Based Contrast Agents is only discussed in one document an….

Panel B shows that at physiological concentrations of zinc, there is no difference between a linear contrast agent (Magnevist) and a macrocyclic agent (Dotarem). Figures C and D show that the gadolinium liberated by magnetic resonance imaging contrast agents and bound to heparin.

Figure 5. At physiological levels of zinc, the relaxivity remains unchanged when Magnevist is incubated with heparin.

But at actual human plasma levels (0.009–0.018 mM, mostly protein-bound), gadolinium remains firmly sequestered. Gadolinium does not exist free from the pharmaceutical ligands or precipitated material in humans.

Schuenke et al. deal a categorical coup de grâce to 'transmetallation' dogma. In Figure 3, zinc is used at supraphysiologic (toxic) levels to dislodge gadolinium from Magnevist and Dotarem.

Observation for Figure 3: 0.125 mM zinc (ZnCl2) had barely any impact on the R1 relaxation rate of Magnevist. The zinc in human plasma ranges from 0.009 to 0.018 mM. Therefore, zinc is not going to displace gadolinium from pharmaceutical ligands in any significant amount.

An NMR relaxometry approach for quantitative investigation of the transchelation of gadolinium ions from GBCAs to a competing macromolecular chelator.

Patient-Centered Advance Care Planning in Dialysis.The HIGHWay (Honor Individual Goals and Hopes Way) Initiative

📣 Are you experiencing chronic symptoms after gadolinium exposure? Our team is conducting confidential, face-to-face interviews for a national registry. 📞 Contact Julie Harris at JuHarris@salud.unm.edu or (505) 925-1065 to learn more.

📊 This publication ranks in the top 5% of all research outputs tracked by Altmetric. With over 10,200 views, 1,200+ downloads, and growing citations, it’s helping shape the evolving conversation on contrast agent safety and retention.

These in vitro values do not reflect physiological conditions. Relying on them to predict in vivo behavior is scientifically specious.

🔬 The Safety of Magnetic Resonance Imaging Contrast Agents — our recent review explores the thermodynamic stability (log(Kₜₕₑᵣₘ)) of gadolinium-based contrast agents. 🔗 Read the review:

"Therefore, these circulating fibrocytes would not be the original ones exposed to the triggering dose of gadolinium-containing contrast agent in the intravascular compartment.".

"Indeed, the circulating fibrocytes found in NSF lesions likely represent a cell population continuously recruited from the marrow because they are CD34+, and the expression of this marker declines once the cells have left the bone marrow.".

"The inflammatory–immune system appears to show “memory” such that once NSF has developed, reexposure to the initial trigger (gadolinium-containing contrast agents) need not occur to sustain disease activity.".

"Most patients with kidney disease who receive a gadolinium-containing contrast agent do not develop NSF, so clearly there are other crucial factors that increase susceptibility to NSF.".

"Reports of increased disease activity coinciding with a decline in renal function need not be explained by decreased clearance of gadolinium mobilized from storage sites such as bone with subsequent deposition in NSF-affected tissues such as skin.".

"Inorganic gadolinium was not tested in this rodent model; however, extensive older studies on the toxicology of lanthanides reported no findings matching those of NSF.".

NSF-Active and NSF-Inert Species of Gadolinium: Mechanistic and Clinical Implications "Published data suggest that administration of gadolinium as a chelate is necessary to cause NSF and therefore that retained inorganic gadolinium is, to coin the term,.