LaboratoryChemicalGlycobiology
@VocadloGroup
Followers
366
Following
7
Media
5
Statuses
29
Group ran account. Here to share research from the group and topics that peak our interest. While David is involved, tweets do not reflect his opinion.
Burnaby, BC, Canada
Joined December 2017
Check out our newest publication led by @MatthewDeen4 and @1981zyp! Herein, we report a new and improved fluorescence-quenched substrate, LysoFQ-GBA, to quantitatively monitor GCase activity in stem-cell derived neurons and PBMCs. https://t.co/4YfvayKYVf
pnas.org
Loss of activity of the lysosomal glycosidase β-glucocerebrosidase (GCase) causes the lysosomal storage disease Gaucher disease (GD) and has emerge...
0
2
14
Nice commentary on new CO2 protein carboxylation paper in NCB. This methods paper enables in vitro mimicry of CO2-protein carboxylation and high-throughput mapping of CO2-modified lysine residues. Inspired by pioneering work of @MartinCann1 and others. https://t.co/tvCdrSIDXA
0
6
15
Support from Sha, @jesus_esn, Zarina, and Kola from the group.
0
0
3
New team paper led by @DustinTKing, SFU's soon to be newest faculty starting on July 18. Big shout out to the entire team on this long haul project. Looking forward to more fun with gases.
3
11
47
I am excited to announce that I will soon be starting as an assistant professor at SFU (July 18th). I am excited to be joining this vibrant research community among so many inspirational colleagues @MbbSfu!
17
3
67
A little late, but congrats to @raashmus for receiving an oral presentation award (2nd place) at SFU's 8th Annual Postdoc Research Day.
0
0
9
The group welcomes visiting student Jun Bian from Josef Voglmeir's group at Nanjing University. She will work on an ongoing collaborative project around deacetylases.
0
0
8
Nice work in ACS Chemical Biology from the Chen team on optimized methods for high-throughput mapping and quantifying of O-GlcNAc. #glycotime
pubs.acs.org
O-linked-β-N-acetylglucosamine (O-GlcNAc) glycosylation is a ubiquitous protein post-translational modification of the emerging importance in metazoans. Of the thousands of O-GlcNAcylated proteins...
0
2
8
The group welcomes Nita Lu, a recent graduate from UofT. She will gain some research experience in developing and evaluating novel glycosidase substrate probes in vitro.
0
0
7
Part of the group having a going away lunch for Viktor at BierCraft UniverCity.
0
0
7
The group says goodbye to research technician Viktor who was a former https://t.co/B9bOkSUMp8. student in the group. Good luck in your future endeavours at Novartis.
1
0
7
Cool new observation: sugaring out of proteins - not caused by glycation. Could open new avenues for research into physiologic effects of high glucose | ACS Chem Biol.
pubs.acs.org
The present study reports a surprising protein-condensing effect of glucose, prompted by our accidental observation during chemical library screening under a high-glucose condition. We noticed...
0
16
69
Fibrils of a fragment TMEM106B discovered in multiple neurodegenerative diseases - a potential important commonality. Great use of cryoEM.
cell.com
Cryo-EM and mass spectrometry-based proteomics of insoluble amyloid fibrils derived from postmortem human brains afflicted with diverse neurodegenerative diseases reveals widespread fibrillization of...
0
0
8
The destabilizing effects found using PTM-TPP for O-GlcNAc are likely mediated by influencing protein complexes. Nice team work with @jesus_esn and Yan as well as Christopher and M Shoulders (MIT) and L Foster (UBC). Hope the methods will be useful for exploring other PTMs.
0
0
8
Newest publication led by @DustinTKing is out in @J_A_C_S. Using thermal proteome profiling, we studied the effects of O-GlcNAc on the stability of proteins and surprisingly found majority of proteins modified are destabilized.
pubs.acs.org
Posttranslational modifications alter the biophysical properties of proteins and thereby influence cellular physiology. One emerging manner by which such modifications regulate protein functions is...
4
18
107
Interesting paper. Metabolic tolerance of sialic acid pathway - Boltje team provides insight into metabolic labeling and metabolic inhibitors of sialylation. https://t.co/78r8ZkW6sh
pubs.acs.org
Sialic acids cap the glycans of cell surface glycoproteins and glycolipids. They are involved in a multitude of biological processes, and aberrant sialic acid expression is associated with several...
0
5
28
The work would be delayed further without the huge support from Pierre, Xi 'Kelly', Matt, Sha, Xiaoyang, and Christina in the group as well as Yang from the @BrittonLab for the preparation of inhibitors.
0
0
4
Our long awaited publication led by @SCecioni and @raashmus is finally out in @nchembio. Herein we describe the development of bis-acetal-based substrate probes that can for the first time measure GALA and NAGAL activity directly in live patient cells. https://t.co/bEWKBG2AeN
3
14
64
The group welcomes our newest member to the team - Dr. Ladan Dawoody. Dr. Dawoody will use her background in cell biology to develop some iPSCs.
0
0
6
Congrats to PhD candidate Ben for receiving recognition from the DGSC and an award for his oral research presentation!
0
0
8