Brain Research & Artificial Intelligence Nexus
@UCLABRAIN
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Dr. @HONGWEIDONG6ai directs the multimodal, multiscale connectome and cell-type map of the mammalian brain through tracing, imaging, and computational methods.
UCLA, Los Angeles, CA
Joined February 2021
The Dong Lab in collaboration with Dr. Jean Shih at USC used a MAO-A KO model to demonstrate neuronal connectivity disruptions caused by elevated serotonin levels, underlying autism and aggression symptoms in humans, can be pharmacologically rescued with early intervention.
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Our warmest wishes for a joyous and prosperous Lunar New Year! #uclabrain #UCLABrainResearchAndArtificialIntelligenceNexus #neuroscience #neurobiology #hongweidonglab
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Happy Holidays from the Dong Lab! Wishing you joy, peace, and success in the season ahead. 🎄❄️✨ #uclabrain #UCLABrainResearchAndArtificialIntelligenceNexus #neuroscience #neurobiology #HongweiDongLab
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Early Postnatal Pharmacological Intervention Rescues the Disruption of Developmental Connectivity in MAO‑A KO Mice.
The Dong Lab in collaboration with Dr. Jean Shih at USC used a MAO-A KO model to demonstrate neuronal connectivity disruptions caused by elevated serotonin levels, underlying autism and aggression symptoms in humans, can be pharmacologically rescued with early intervention.
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Meet Mitchell. He leads our tissue clearing and 3D imaging pipeline, and is spearheading several methods development projects. On any given day you can find him around the lab, playing soccer, or hanging out with friends. #uclabrain #hongweidonglab
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Our office is right next to a botanical garden filled with amazing flowers and trees. The beauty of the garden is truly inspiring and sparks fresh ideas every day. 🌿💡 Cherishing the amazing backdrop that inspires our creativity! 🌺🌿 #uclamathiasbotanicalgarden #uclabrain
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Our Summer volunteers presented their work today. We have close to a thousand neurons reconstructed over the summer. #uclabrain #UCLABrainResearchAndArtificialIntelligenceNexus #neuroscience #celltypemap #singlecellanalysist #mousebrain #neuronreconstructions #HongweiDongLab
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UCLA, USC and UCLA again. One cozy staple throughout incarnations of the Dong Lab: potlucks at Hongwei's house. Here are comfortable scenes from the UCLA BRAIN Summer 2024 potluck. :tada: :partying_face:. #uclabrain #UCLABrainResearchAndArtificialIntelligenceNexus #HongweiDongLab
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This month, the UCLA Dept of Neurobiology retreat was held at Santa Monica Beach. BRAIN Lab members took part in the fun activities followed by science talks!. #uclabrain #UCLABrainResearchAndArtificialIntelligenceNexus #HongweiDongLab
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UCLA Brain Research & Artificial Intelligence Nexus at #LABEST2024 conference last week!! Thank you @AFP @UCLATDG .
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UCLA BRAIN renovations were completed in August of 2023! So much more to come. #uclabrain #UCLABrainResearchAndArtificialIntelligenceNexus #neuroscience #neurobiology #multimodalconnectome #multiscaleconnectome #celltypemap #HongweiDongLab
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Note close proximity of our engineering and medical schools. The Data Science in Biomedicine MS is an exciting program.
Announcing the Data Science in Biomedicine MS program .@UCLAHealth @UCLAengineering #masterdatascience #biomedicine #DataScienceCourses
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Esther, Mitch and Adriana with a new lab space sneak peek. @UCLABRAIN is a proud part of the @UCLA Department of Neurobiology
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Work from @UCLABRAIN professor Dr. Houri Hintiryan traced hundreds of pathways to identify novel BLAa cell populations with distinct connections👉showing how connectivity data facilitates hypothesis generation for behavioral interrogations
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A study from @UCLABRAIN postdoc @QiuyingZhao demonstrates that maternal inflammation during pregnancy perturbs blood-brain barrier formation, potentially an etiological factor contributing to the pathology of neurodevelopmental disorders of offspring
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Dr. Joel Hahn's graphical abstract for the functional associations of the LPO and LHAa. Three nested tiers are represented, and regions are color-coded by major brain division (shown in flatmap insert) and listed in a topographic arrangement
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Work from @UCLABRAIN Project Scientist @JiandongSun21 details LAMTOR1-mediated inhibition of TRPML1 critical for regulating dendritic lysosomal motility, synaptic plasticity, and learning.
Xiaoning Bi and coworkers @WesternUNews find #Ragulator subunit #LAMTOR1 to inhibit #lysosomal #calcium release via #TRPML1 – to control #dendritic lysosome trafficking and #hippocampal neuron function.
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Dr. Joel Hahn's color-coded flatmap of the vertebrate central nervous system -- an open-access resource to perform comparative analysis of brain data. The template is used for rat and mouse; an updated human brain flatmap uses an identical color scheme
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The cortico-tectal projectome of @Lucid_Primate @UCLABRAIN provides a structural basis for understanding how this system integrates sensory modalities, translates sensory information into motor commands, and coordinates action in goal-directed behaviors
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