GEM Project
@The_GEMProject
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The official Twitter account of the Genetic, Environmental, Microbial (GEM) Project. @sinaihealth supported by @getgutsycanada & @HelmsleyTrust
Toronto, Ontario
Joined March 2017
🚨 Don't miss the latest article from @IMSMagazine covering @SunHoLee15 work with the GEM Project! With GEM’s unique dataset, Dr. Lee is helping to pave the way for precision medicine in IBD care and prevention. #PrecisionMedicine #IBDResearch
imsmagazine.com
By Mia Feldman
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RT @HelmsleyTrust: Innovative research is essential for enhancing our understanding of Crohn’s disease and advancing the development of fut….
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Congratulations to @AlexanderLuchak.for successfully defending his PhD at the Department of Immunology @UofT! Alec's work in murine models of IBD has helped uncover potential mechanisms of IBD @KenCroitoru #DanaPhilpot @TheGEMProject @TurpinWilliams @Sunholee15 @BHUPESHTHAKUR30
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RT @SunHoLee15: Special seminar by @eytan_wine about “Gut microbes as a therapeutic target in IBD” @UofT_DoM @UofTGastroHep @SinaiHealth….
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RT @SunHoLee15: Excellent talk about Role of anti-microbial immunity in IBD @ivanvujk at the Biology of IBD Rounds @SinaiHealth @UofTGastro….
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RT @SunHoLee15: Accelerating discovery to improve IBD care | Sinai Health . @KenCroitoru @The_GEMProject @TurpinWil….
sinaihealth.ca
Canada has one of the highest rates of inflammatory bowel disease (IBD) in the world, with a staggering one in 140 Canadians affected by the condition. To date, there is no cure for this lifelong...
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You can also see the full manuscript here:Â . @MingyueXue @HaimLeiboIBDÂ @SunHoLee15Â @TurpinWilliams @KenCroitoru @getgutsycanada @HelmsleyTrust.@JeanFredericCo1 @ManasiAgrawalMD @JoanaTo62523004 @DrTineJess".
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Our findings linking microbial and environmental factors to CD risk were highlighted in a recent post from @GMFHx! Check out the link below:
gutmicrobiotaforhealth.com
Whether environmental and microbial factors are the cause or consequence of Crohn’s disease is still subject to debate. Two recent studies by the Crohn’s and Colitis Canada—Genetic, Environmental,...
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We would like to thank our global team and our funding agencies. This study has been a great team effort, and we extend our gratitude to all participating sites and, of course, all participants. 7/8.
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The GEM Project study provides the first insight into the potential biological mechanisms of environmental factors in Crohn’s Disease pathogenesis. 6/8.
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Taking advantage of our unique cohort, we uncovered that the environmental factors associated with future CD development were associated with altered barrier function, subclinical inflammation, and shifts in gut microbiome composition. 5/8
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We next aimed to go beyond disease prediction and gain deeper biological insight to better understand how these environmental factors may contribute to disease onset. 4/8.
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living with a dog between ages 5-15 and living with a large family size in the first year of life, were associated with a decreased Crohn's disease risk; whereas having a bird at the time of recruitment was associated with an increased Crohn's disease risk. 3/8
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4,289 healthy first-degree relatives of CD patients from the Crohn's and Colitis Canada - GEM) project were followed a median 5.62 years, among which 86 developed CD. We discovered environmental variables associated with the risk of disease, including 2/8.
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New data from The GEM Project: led by @MingyueXue et al, published in CGH. This study identifies environmental variables associated with the future risk of Crohn’s Disease, the pathogenic mechanism of which can potentially be explained by some identified CD-risk biomarkers. 1/8.
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RT @SunHoLee15: #KathyVagianos @TurpinWilliams presenting Ultra-processed food, gut microbiome and intestinal inflammation in first degree….
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RT @h_sokol: Environmental Factors Associated with Risk of Crohn’s Disease Development in the CCC-GEM Project - Clinical Gastroenterology a….
cghjournal.org
To date, it is unclear how environmental factors influence Crohn’s disease (CD) risk and how they interact with biological processes. This study investigates the association between environmental...
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Click to learn more about the GEM teams groundbreaking work defining key characteristics of pre-clinical Crohn's disease. We'd like to thank @imkasid2024 for the invitation and @getgutsycanada for their support towards these important discoveries.
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RT @GMFHx: Bacterial proteases are involved in Crohn’s disease. @KenCroitoru shares recent data from @VerduLab supporting that specific m….
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