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[6/n] 8. Disproportionate effect of sterility genes in Haldane’s rule 9. Evolution of slower autosomal regulatory hybrid breakdown at later stage of speciation

[5/n] 4. Evolution of distinct somatic vs germline dosage compensation 5. Haldane’s rule 6. Darwin’s corollary to Haldane’s rule 7. Large X effect (or Z)

[4/n] It works very well, and explains a lot with few assumptions: 1. Recombination arrest between sex chromosomes 2. Degeneration of the Y (or W) 3. Evolution of dosage compensation

[3/n] The main effect is caused by regulatory divergence between incipient species, especially concerning dosage compensation. This idea, often mentioned, and often dismissed, has not been fully explored theoretically.

[2/n] This theory differs from the well-known “dominance theory” and specifically links the evolution of sex chromosomes to the “rules of speciation”.

[1/n] This theory uses the same model that we previously built to explain the evolution of non-recombining, degenerate and dosage-compensated sex chromosomes.

We propose a single theory for the evolution of sex chromosomes, Haldane’s rule and the large X effect https://t.co/PE6B3Tlhyc [thread]

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Sex Unfolded J Monod Conference 3rd edition in incredibly sunny Roscoff. Already 1 week ago. Thanks to all participants! Many new ideas for the #evolutionofsex #recombination, #SexChromosomes #asexuality #evobio #popgen. 4th edition in 5 years by @KarineDoninck and Sylvain Glémin

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Please RT. Registration now OPEN for #SexUnfolded: sex, asex, sexes. Jacques Monod Conference. Third Edition in beautiful Roscoff Sept. 11-15 2023 Registration and details here: https://t.co/dWW3LJMELq

Update on the upcoming Jacques Monod Conference: SEX UNFOLDED : SEX, ASEX, SEXES September 11-15, 2023 in Roscoff, France. The list of invited speakers and details are here: https://t.co/h9KzXKGiZn The application website is not yet open but will be soon. Stay tuned!

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Please RT. Sex Unfolded: sex, asex, sexes. Jacques Monod Conference. Third Edition in beautiful Roscoff in sept 11-15 2023. Mark down in your agenda! Registration information will follow soon. #evolutionofsex #recombination, #SexChromosomes, #meiosis, #sexualconflict, #genomics

7/n A visual summary of those steps

6/n Step 4 = Hence, few inversions end up persisting a very long time. They become highly degenerate and dosage compensated, definitely removing the possibility of a reestablishment of recombination on the long term. The process repeats itself for several strata. Et voila.