🔗Check out the full paper here to dive deeper into these findings: https://t.co/i4yMgjipdU #Research #RasMAPK #Neuroscience #NoonanSyndrome #NF1 #Neurodevelopment #WhiteMatter Thank you @ntapresearch for funding this work.

Our findings highlight that the Ras-MAPK pathway plays a key role in white-matter development in children, influencing connectivity & social communication. (7/7)

Our findings highlight that the Ras-MAPK pathway plays a keyrole in white-matter development in children, influencing connectivity & social communication. (7/7)

Overlap between NS & NF1 emerged in radial & mean diffusivity, suggesting shared effects on white-matter integrity.

Despite the genetic differences between the two syndromes, both #Noonan syndrome and #NF1 result in similar social difficulties across affected groups.

Intra-hemispheric tracts like the arcuate and superior longitudinal fasciculi, critical for social communication, are impacted—linking these variants to social difficulties in both #Noonan and #NF1 patients.

Key findings: Noonan syndrome and Neurofibromatosis type-1 (NF1) show distinct spatial patterns and magnitudes of impact on white matter tracts, as seen in fractional anisotropy and axial diffusivity. 4/7

🧠 Noonan syndrome (NS) & Neurofibromatosis type-1 (NF1) exhibited distinct impacts on white-matter microstructure. Using fractional anisotropy (FA) & axial diffusivity (AD), we observed differences in intra- & inter-hemispheric tracts. (3/7)

We used diffusion neuroimaging to uncover how pathogenic variants in the Ras-MAPK pathway affect brain development, particularly white-matter structural connectivity. Here’s what we found 👇(2/7)

🧵 Excited to Share Dr. Monica Siqueiros-Sanchez's latest paper on the impact of pathogenic variants in the Ras–mitogen-activated protein kinase (MAPK) pathway on white matter tracts in the human brain. (1/7)

NTAP is #HIRING! If you are a recent grad or have Physician Asst. / Nurse Practitioner entry-level experience, apply to this position on our #NF team that sees patients in the clinic and trials. Physician Asst: https://t.co/XefQ1eoLXv Nurse Practitioner: https://t.co/4bXOzN6ML8

I had the honor and pleasure of sharing my thoughts on the research and care for children with #ADHD, #Autisem and #RASopathies, specificaly #NF1 and #Noonan Syndrome. @ChildrensTumor; @ntapresearch; @StanfordMed

Great talk! Just at the QnA, a child pulled the fire alarm 😂 So reach out if you have questions for Dr Serur or @BridgelabU btw: it was a false alarm

Speaking today the #GNC24 at beautiful Porto was such a pleasure. I enjoyed sharing our #geneticfirst work on #RASopathies and hearing about the great work at #Payne lab. @RASopathiesnet @BridgelabU @ChildrensTumor @ntapresearch

6/6 Full paper is here https://t.co/uzf8iHArCy. A very special thanks to the children and families who participated and the members of @ntapresearch @NICHD_NIH @NoonanSyndrome1 @StanfordMed @StanfordPSY @RASopathiesnet

5/6 When looking at the syndrome level, #Noonansyndrome and #Neurofibromatosistype1 have a converging effect on surface area and cortical thickness but a diverging effect on subcortical volumes.

4/6 Additionally, we found that #Noonansyndrome had overall decreased subcortical volumes, whereas #neurofibromatosistype1 had increased subcortical volumes.

3/6 Compared to typically developing children, children with RASopathies result in thinner cortices in the precentral gyrus.

Our vertex-based analysis found that children with RASopathies display several alterations in surface area across the cortex compared to typically developing children. Both #Noonansyndrome and #Neurofibromatosistype1 had decreased surface area in the occipital regions.

1/6 #ChloeMcGhee latest research on neuroanatomical variation in children with RASopathies, specifically, Noonan Syndrome and Neurofibromatosis type 1 was published today in BP:CNNI @BiologicalPsyc1, a 🧵😍