BRIDGE Lab - Stanford University
@BridgelabU
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The BRIDGE Lab at Stanford is dedicated to researching the effect of altered genetics on brain development and neuropsychiatric conditions.
Joined June 2023
Thank you to the children, families, and collaboratorsfor making this work possible. @TamarGreenLab
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These findings highlight the need for tailored supports, as nearly 30% of individuals with NS/NSML show autism-related behaviors.
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Importantly, higher SHP2 activation levels were associated with greater likelihood of clinically significant restricted/repetitive behaviors.
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We found that children with PTPN11- and SOS1-associated NS/NSML show elevated autism-related traits, reduced social functioning, and more emotional challenges. NSML was also linked to increased attention problems.
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Our latest study in Molecular Autism examines genotype–phenotype connections in children with RASopathies, focusing on #autism-related behaviors in Noonan Syndrome (NS) and NS with Multiple Lentigines (NSML).
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Thank you to The Banbury Center for fostering thoughtful dialogue and collaboration aimed at improving understanding and care for individuals with NF1.
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The meeting focused on Cognition and Behavior in Neurofibromatosis Type 1 (NF1) and brought together leading researchers and clinicians to discuss recent advances and future directions in the field.
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We were honored to have Dr. @TamarGreenLab represent the BRIDGE Lab at the Banbury Center at Cold Spring Harbor Laboratory last week.
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A huge thank you to all who contributed their expertise and lived experience. Excited for the collaborations and concrete next steps ahead. @StanfordMCHRI
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The day closed with a focus group and synthesis session, where we began charting a shared vision for advancing interventions in RASopathies.
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Together, we explored gaps in the basic science, translational research, and clinical perspectives of RASopathies. We also heard powerful reflections from the Penny Flight Foundation and had a great perspective from the Gilbert Family Foundation.
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Earlier this month, we gathered for the 2025 RASopathies Research Summit for a day of collaboration between families, researchers, clinicians, and advocates.
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BRIDGE Lab’s Julia Plank, PhD recently presented her poster, “Functional brain networks predictive of cognitive function in children with Noonan Syndrome” at the 2025 Summer Conference on The Changing Brain.
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Congrats! Excited to see the next generation of scientists driving discovery for the NF1 community. Make this summer count! 🔬🧬 #NF1 #Research #FutureScientists #SummerInterns #TeamScience
Please join us in welcoming our amazing summer interns to BRIDGE Lab! We’re thrilled to have Tali, Catalina, and Annetta join the team. Each of them brings curiosity, enthusiasm, and fresh perspective to our work, and we’re excited to learn and grow together this summer.
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Featuring Dr. Philip Fisher and Dr. Alan Atkins, this session shares research insights and practical tools to support parents and caregivers of children with rare genetic conditions.
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Missed our recent BRIDGE Lab webinar on Managing Parent Burnout in Rare Genetic Populations? You can now watch it anytime:
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Importantly, these patterns differed across genetic variants (PTPN11, SOS1, and others), offering new insights into how genes influence brain development and pointing toward future precision medicine strategies.
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Beyond confirming known reductions in subcortical volume, we found more complex, region-specific changes in areas such as the putamen, thalamus, and accumbens.
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