Stephen Dolan
@StephenKDolan
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Assistant Professor at @ClemsonUniv. Fascinated by all things microbiology. 🇮🇪
Clemson, South Carolina
Joined May 2017
@EPICClemson @ClemsonUniv Now published at @PNASNews! . Convergent evolution in toxin detection and resistance provides evidence for conserved bacterial–fungal interactions | PNAS.
pnas.org
Microbes rarely exist in isolation and instead form complex polymicrobial communities. As a result, microbes have developed intricate offensive and...
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RT @Gina_Lewin: Postdoc(s) available in my lab!. Multiple projects on how bacterial genomic and functional diversity impacts microbial inte….
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RT @Carlos_parq: Check out our latest preprint on RNAi epimutations!🧬Our team has shown how spontaneous RNAi-based….
biorxiv.org
Epimutations modify gene expression and lead to phenotypic variation while the encoding DNA sequence remains unchanged. Epimutations mediated by RNA interference (RNAi) and/or chromatin modifications...
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RT @plant_planet_CU: @clemson_biolsci is hiring 4 TT faculty!.Microbiome EEOB 2 positions E….
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RT @biorxiv_micrbio: Staphylococcus aureus Phenol-Soluble Modulins Mediate Interspecies Competition with Upper Respiratory Commensal Bacter….
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RT @clemson_biolsci: We're hiring! .𝗔𝘀𝘀𝗶𝘀𝘁𝗮𝗻𝘁 𝗣𝗿𝗼𝗳𝗲𝘀𝘀𝗼𝗿 - 𝗗𝗲𝗽𝘁 𝗼𝗳 𝗕𝗶𝗼𝗦𝗰𝗶 𝗮𝗻𝗱 @EPICClemson .Visit for full details….
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Thanks to @ClemsonUniv for highlighting our work!.
Stephen Dolan, assistant professor for @ClemsonScience, has revealed previously unknown information about how bacteria and fungi interact in the lungs of people with cystic fibrosis (CF)! CF is one of the most common genetic diseases in the United States.
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RT @KamounLab: Gordon Research Conferences (GRCs) have issues with their outdated take on confidentiality. Feel free to tweet my talk ton….
kamounlab.medium.com
I’m surprised at how many in the biology community don’t seem to know about the “scooping Protection” policy that many journals have…
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RT @KidsLungDoc: Great work Casey! Pseudomonas aeruginosa Lipid A Structural Variants Induce Altered Immune Responses | American Journal o….
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Very excited to continue this research on polymicrobial interactions in cystic fibrosis @CF_Foundation at @EPICClemson and @clemsongenbio.
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A big thanks to everyone who helped me put this together; @whiteleylab, @GaTechMicrobes, @EmoryCHOA_CFAIR, @cramer_lab, @KevenRobinson6 and @ACasadevall1. A special thanks to @CBIbberson for lots of help with the application process.
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RT @Quinn_Labs: Finally out!! Our new manuscript on Bile Salt Hydrolase as the producer of microbially conjugated bile acids is out in @Nat….
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RT @CF_Foundation: Today is #WorldAspergillosisDay. Aspergillosis is an infection caused by Aspergillus, a common fungus in our environment….
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RT @ASMicrobiology: #MicrobiologyMonday: In the absence of neutrophils, macrophages do a good job of slowing down growth of Aspergillus fum….
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I am currently expanding on this work with my group at the Eukaryotic Pathogens Innovation Center @EPICClemson at @ClemsonUniv. Lots more data to come!.
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Thank you to Ashley Duong, who made valuable contributions as a @GeorgiaTech undergraduate. Wishing her all the best with her med school applications! And cheers to @floodedbridges who insisted that DnpO is a pretty lame abbreviation for a new protein and proposed DnoP instead.
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Thanks to everyone at @CamBiochem, @GaTechMicrobes, Marvin, and all @whiteleylab who made this work possible. In particular, the Cambridge Herchel Smith Fund for giving me the independence to explore interkingdom interactions, and the @CF_Foundation for their fellowship support.
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DnoP and its transcriptional induction by low zinc represent a rare example of both convergent evolution of toxin defense and environmental cue sensing across kingdoms. This work is evidence that Pa has evolved to survive exposure to these molecules in the natural environment.
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