Sriram Garg
@Sriramgarg
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RT @KaHochberg: Our latest preprint: @Sriramgarg calculate a general substitution matrix for structural phylogenetics and used it to root….
biorxiv.org
Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the evolutionary histories of proteins and the organisms...
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Greetings Phylogenetic aficionados! We humbly present “A general substitution matrix for structural phylogenetics.” Estimated using QMaker and AF structures. Hope this continues to inspire more investigations in the field
biorxiv.org
Sequence-based maximum likelihood (ML) phylogenetics is a widely used method for inferring evolutionary relationships, which has illuminated the evolutionary histories of proteins and the organisms...
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RT @KaHochberg: Check out this paper from the Bode group, which we contributed a little bit to. These enzymes have very bizarre evolutionar….
science.org
Bioinformatic analysis reveals sequence sites ideal for engineering in enzymes that produce non-ribosomal peptide natural products.
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RT @DdelAlamo: Predicting structures of large protein assemblies using combinatorial assembly algorithm and AlphaFold2. This approach "exha….
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It is always refreshing to see after a difficult peer review 2/3 reviewers had similar thoughts. Now my anxiety can choose a different topic!! #peerreview #science #academia.
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RT @KaiserSebastian: Check out the latest publication of @Steube_N and @KaHochberg. Awesome work in which they show how protein protein in….
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RT @Steube_N: Check out our latest paper @KaHochberg @mpi_marburg in fruitful collaboration w/ Marcus & Thomas @TUBerlin featuring blind ch….
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"The internalisation of a symbiont cell within an archaeal host cell in the absence of phagocytotic machinery is relevant for models on the origin of the eukaryotic cell.". Very cool indeed!.
biorxiv.org
DPANN Archaea are a diverse archaeal clade characterised by small cells and reduced genomes. To date, all cultivated DPANN Archaea are ectosymbionts that require direct cell-cell interactions with a...
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How appointments work in Germany. Me: Can I get an appointment for an MRT? .Them: Next February .Me: Morning or Afternoon .Them: What difference does it make one year from now?.Me: The electrician will come in the morning!.
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Can't believe I missed this! Is this why eyesight drops due to ageing??. Mitochondria in cone photoreceptors act as microlenses to enhance photon delivery and confer directional sensitivit…
pubmed.ncbi.nlm.nih.gov
Mammalian photoreceptors aggregate numerous mitochondria, organelles chiefly for energy production, in the ellipsoid region immediately adjacent to the light-sensitive outer segment to support the...
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RT @fburki: Reconstruction of plastid proteomes of apicomplexans and close relatives reveals the major evolutionary outcomes of cryptic pla….
pubmed.ncbi.nlm.nih.gov
Apicomplexans and related lineages comprise many obligate symbionts of animals; some of which cause notorious diseases such as malaria. They evolved from photosynthetic ancestors and transitioned...
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Microbial predators form a new supergroup of eukaryotes | Nature
nature.com
Nature - Provora is an ancient supergroup of microbial predators that are genetically, morphologically and behaviourally distinct from other eukaryotes, and comprise two divergent clades of...
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This was awesome to be part of! Eukaryotic Cell biology is coo-mmm-plex!!. Mitochondrial presence/involvement observed to be ubiquitous. Everything in between. Fertile Food for thought!!. #eukaryogenesis #mitochondria #complexlife.
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RT @HUBBLE_space: 1/ This Hubble picture of the week shows two galaxies in the galactic triplet Arp 248 or Wild’s Triplet. The two large sp….
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RT @KaHochberg: Our paper about the evolution of a particularly important type of the CO2 fixing enzyme Rubisco is out in Science today. If….
science.org
Ancestral sequence reconstruction reveals how recruiting a new subunit primes form I Rubiscos for rising atmospheric oxygen.
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RT @aschneiderlab: The tripartite attachment complex in T. brucei: p197 determines the distance between the basal body and the mitochondria….
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RT @BrianNosek: Massive status bias in peer review. 534 reviewers randomized to review the same paper revealing the low status, high statu….
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RT @Markinthelab: Removed myself as an Frontiers Editor today. Frontiers seems to be adopting a MDPI style system, gaming IF whilst pushing….
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