New paper alert 🚨 I am excited share our recent publication from @BZhangLab in @LabonaChip on biofabricating vascularized crypt-patterned colon tissues for drug screening and IBD-like modelling. Check it out here: https://t.co/KL49NNaqX9

Join us in Belgrade this Fall for an amazing @Nature conference on Engineering Models of Disease amazing speakers and super low registration fee ($75) under skilled leadership of @ChristineHorejs https://t.co/I8mPhkyURO

Super cool pitch by @Organo_Biotech CEO @Boyangzhang We use their technology all the time-they are best in class #organonachip #organoid

It was awesome to open the day with a Keynote at @MPSWorldSummit yesterday @CRAFT_mfluidics @acceleration_c booth was super well visited, great to see so many alumni @ZhaoYimu #organonachip #organoid

Imagine growing a miniature version of the human intestine in the lab to study gut biology in great detail and test medicines before clinical trials? We are happy to share our latest publication on bioengineered human mini-intestines: https://t.co/0AvDkk9R3S Let’s dive in!

Check out my interview with @Independent featuring our #smart #food #packaging #technologies. We should all work together to prevent food #waste and resolve food #insecurity. @McMasterU @McMasterEng https://t.co/GbKReeY50u

We’re proud to be part of this tremendous success story! It started with Prof. Valliant’s innovative idea. Now @FusionPharmaInc is a clinical-stage biopharmaceutical company being acquired by @AstraZeneca in a deal valued at as much as $2.4 billion (US).

New paper alert🚨 So excited to share my recent publication from @BZhangLab in Advanced Healthcare Materials on biofabricating early- and late-stage models of the placental barrier. Check it out here: https://t.co/gR0Wx7r82z

New paper alert🚨 We are excited to share our latest publication from @BZhangLab in Adv Healthc Mater. We show a pumpless platform that facilitates longterm recirculating flow of 3D printed tubular tissues using a programmable rocker. Check it out here: https://t.co/skOqx7TV1D

I am honoured to be named a NSERC #VanierCanada Scholar! Deep gratitude to the driving forces behind my research journey: @BZhangLab, the Department of Chemical Engineering, and the School of Biomedical Engineering @McMasterU

Congratulations to the seven McMaster doctoral students who have been named recipients of the 2023 Vanier Canada Graduate Scholarship | @mcmastersgs @McMasterEng @machealthsci @McMasterSocSci

We're #MacEngProud to share that two of our graduate students have been named Vanier Scholars. 👏 🔥 Kholoud Abousalem 🔥 Alexander Sotra Learn more about their research and academic journeys: https://t.co/PFpBy6quaP

A #vascularized crypt-patterned colon model for high-throughput drug screening and #disease modelling Alexander Sotra @SotraScience, Kimia Asadi Jozania & Boyang Zhang @BZhangLab @McMasterEng https://t.co/6QT5fsPwpm

Congratulations. Alex @SotraScience , and Boyang @BZhangLab. By all means, let's recreate it next time with the liver. @StemCellNetwork , Impact award 2023. IFLOW Plate!!

Thanks to my co-author @KimiaAsadij and our funding agencies @NSERC_CRSNG @CIHR_IRSC for making this work possible. @BZhangLab @Mac_ChemEng

Lastly we induced inflammation and found vasculature released cytokines for potential immune cell infiltration (IL-1β, IL-6, IL-8) and polarization (GM-CSF, IL-12p70) which was absent in avascular tissues. This underscores the importance of integrating vasculature for IBD studies

We then incorporated a microvascular network interacting with the crypts. HUVEC and fibroblasts self-assembled to form blood vessels at the bottom of fibrin gels and were ~70 µm from crypts. This close proximity suggests potential crosstalk between epithelium and vasculature

We found proliferative cells (red) could spontaneously localize within the crypts compared to planar tissues as well as crypt-patterned tissues without basolateral flow. The results illustrate the significance of both crypts and basolateral flow for in vitro colon models.

A short thread 🧵 highlighting our key findings, We developed a method to pattern fibrin hydrogels with a crypt topography and populate the crypts with colon cells of ~600 µm depth and observed minimal gel remodelling.

I am grateful to have had the opportunity to present my research from @BZhangLab at the 2023 @CanBiomatSoc conference! A huge thank you to the @DalhousieU organizers for hosting an enriching event that fostered collaboration and scientific exchange in beautiful Halifax