#crushingit in Gainesville!!! The UF lab is renovated and ready, students have safely made the trip, and @JovicaTodorov1 's enkephalin paper is featured as a cover for Analytical Chemistry! Artwork credit goes to our own @OneMetricDylan .

Gracey McNair representing the NC contingent of the lab at the NCSU Chem undergraduate research poster sesh. Inspiring young minds !! 💪👍 Go Gracie!!

Congratulations to Greg McCarty, Carl Meunier and the whole team!!! #cantstopwontstop, #electrochemists, #somuchpotential 👏💪.

The modified electrodes exhibited enhanced selectivity for smaller peptide species over larger peptides in a manner consistent with the size of the dioxythiophene monomer incorporated into the polymeric film, allowing for tunability in terms of size-based selective detection.

The modified electrodes were characterized in the voltammetric detection of dopamine and a series of tyrosine containing neuropeptides of increasing size: met-enkephalin (M-ENK), oxytocin (OXY), neurotensin (NT), and neuropeptide Y (NPY).

When using electrochemical detection strategies in live tissue, we are always worried about selectivity. Here, dioxythiophene monomers were mixed with Nafion and used to create a membrane with nanostructured pores of increasing size.

#CRUSHINGIT at UF with another new paper out in ACS Sensors! We electrodeposited polymer films on the electrode that allow for the tunable, size-based exclusion of larger molecules.

Thank you @Kalynn_mckenzie, @OneMetricDylan and the whole team for this awesome graphic!! You rock!

RT @dominickmatthew: Timelapse flying by Hurricane Milton about 2 hours ago. 1/6400 sec exposure, 14mm, ISO 500, 0.5 sec interval, 30fps….

This week was national postdoc appreciation week and we want to give a shoutout to our awesome postdoc, @JovicaTodorov1! Jovica studied voltammetry as a grad student at NCSU, and as a postdoc at UF he is learning electrochemical impedance spectroscopy 💪 #somuchpotential

UF academic year kickoff - here's to new beginnings! Wish @JennaBerger4 was here too! 🧡

THIS! This is the Sombers Lab!! These are the amazing people who have done the work since we began at NCSU in 2008, through the present at UF. Training these researchers is my most significant contribution to science and I am so proud. Go Team!!!

See the paper here!👇 @ACS4Authors #MyACSCover.

A factory is used to represent synthesis of custom peptides cleaved from pro-enkephalin. The illustration shows a team of scientists seeking to understand detection of these peptides using electroanalytical signatures dictated by chemical structure.

Jovica Todorov is crushing it!!!! #cantstopwontstop!!!! DM us if you'd like to see the whole article 💪.

Overall, this study demonstrates how fast-scan cyclic voltammetry can be utilized to discriminate between peptides with small differences in the chemical structure, thus establishing a framework for reliable quantification of small peptides in a complex signal, broadly speaking.

Finally, the work uses the electrochemical signal for individual amino acids in a “training set”, with a combination of principal component analysis and least-squares regression to accurately predict the voltammetric signal for short peptides comprised of different combos of aa's.

Both the proximity of the electroactive residue to the C- or N-terminus and the hydrophobicity of the additional nonelectroactive amino acids profoundly affect sensitivity.

@JovicaTodorov1 NMR spectroscopy was used to determine the structure and conformation at near-physiological conditions. Voltammetric data demonstrate how the peak oxidation potential and the rate of electron transfer are dependent on the local chemical environment.

Dr @JovicaTodorov1 synthesized ENK, smaller bits of ENK, and larger ENK-containing peptides that come from the larger peptide precursor, pro-ENK. Sometimes he just swapped the order of the amino acids.