Simon Fandler-Höfler
@SimonFaHo
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Neurologist focussing on intracerebral haemorrhage, stroke and neurological emergency medicine @MedUniGraz, Austria and @UCLStrokeRes
Graz
Joined June 2023
(1/3) In which patients with intracerebral hemorrhage should advanced work-up such as digital subtraction angiography be performed? The MACRO score may help - using a few simple MRI parameters it allows to reliably assess the risk of macrovascular causes:
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RT @stephanamayer: This is a breakthrough study that forges a new future — POC biomarkers for identifying #ICH in the prehospital phase.….
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RT @StrokeAHA_ASA: #STROKE: In patients with acute ischemic stroke, admission NT-proBNP may predict the in-hospital development of atrial f….
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RT @StrokeBern: How do chronic ischemic lesions differ in patients with #AtrialFibrillation and #SmallVesselDisease? .We compared MRIs from….
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RT @DavidSeiffge: EURECA: New data on recurrent ICH: every second recurrence is adjacent to index ICH. Those bleedings occur early and are….
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RT @DrGargiBanerjee: New in @JNNP_BMJ - the next chapter in the story of iatrogenic CAA 📕 and it really does seem to be different to sporad….
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RT @HOzkan92: Our meta-analysis of 279 stroke studies over 24 years, with 117K+ participants, found that 1 in 2 stroke patients experience….
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RT @UCLStrokeRes: Check out our latest paper providing the most comprehensive description of the phenotype and natural history of iatrogeni….
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4/4 This indicates that patients with iCAA appear to have distinctive MRI characteristics, which might differentiate iCAA from other CAA subtypes and provide new insights into disease mechanisms. @DrGargiBanerjee @UCLStrokeRes @BenStorti @KKaushikMD.
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3/4 Besides severe CAA on MRI, we found:.a) major progression of CAA markers over 4 years.b) ipsilateral-dominant spread of haemorrhagic lesions (from amyloid-beta exposure).c) frequent deep microbleeds.d) frequent inflammatory changes.e) very frequent small intragyral ICH.
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2/4 Over a median follow-up of 4 years, there were 43 symptomatic ICH in 24 patients (16.7 per 100 patient-years) plus 36 asymptomatic ICH visible on follow-up imaging. We centrally evaluated 219 MRIs (which was a very interesting experience)!.
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1/4 Iatrogenic cerebral amyloid angiopathy (iCAA) is a scary rare disease affecting patients 30-50 years after possible CNS exposure to pathological amyloid-beta. In a large international collaboration, we investigated neuroimaging findings and clinical outcomes in 51 patients.
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RT @GreenJournal: This case highlights the diagnostic approach and importance of thorough clinical evaluation of young patients with intrac….
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RT @raafiahmussa: Thrilled to share my first manuscript from my PhD research on stroke in young adults!. Our study highlights key factors a….
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RT @UCLStrokeRes: First paper from the UCL Young Stroke Systematic Evaluation Study (ULYSSES) @ESOstroke @raafiahmussa @HOzkan92 Open Acces….
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RT @DrGargiBanerjee: We tend to think of CAA-related inflammation as its own separate thing - but is this right? . @AminaSellimi @UCLStroke….
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RT @UCLStrokeRes: Left atrial appendage occlusion in patients with #AFib atrial fibrillation and #stroke due to intracerebral haemorrhage a….
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RT @UCLStrokeRes: By popular demand here's a shareable link - - to our Review on #stroke due to #intracerebralhaemo….
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RT @GreenJournal: Fandler-Höfler and colleagues created and validated a risk stratification score for macrovascular causes of intracerebral….
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RT @DavidSeiffge: Great to see our review on intracerebral haemorrhage now published in @NatRevNeurol ! Great collaboration with @SimonFaHo….
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