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Shawn Shortill Profile
Shawn Shortill

@ShawnShortill

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PhD, Medical Genetics from @UBC @CMMT_UBC 🧬 Investigating synthetic lethality in DNA repair pathways @BCCancer šŸ„ Opinions are mine, RT/like ≠ endorse

Vancouver, British Columbia
Joined January 2021
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@ShawnShortill
Shawn Shortill
3 years
I’m very excited to share that my PhD work is now published @eLife! We used a combination of genetics, cell biology and biochemistry to identify a new endosomal complex in yeast, which we named VINE 🌿 Early access here: (1/n).
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elifesciences.org
The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
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@ShawnShortill
Shawn Shortill
2 years
RT @DdelAlamo: "Reliable protein-protein docking with AlphaFold, Rosetta and replica-exchange". Some promising results on antibody-antigen….
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@ShawnShortill
Shawn Shortill
2 years
Interesting paper, awesome name for a shortened BAR domain!.
@TMDCLab_Pasteur
Echard Lab, Pasteur Institute, Paris
2 years
MiniBAR has a unique truncated BAR domain, is a dual Rac / Rab #GTPases effector and controls both actin cytoskeleton and membrane trafficking in ciliogenesis. #RabGTPases #RhoGTPases #actin #myosin #membranetraffic #ciliopathies #zebrafish #cilia
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@ShawnShortill
Shawn Shortill
2 years
Yeast friends—this is an interesting approach to getting around stubborn, tag-intolerant proteins for imaging studies.
@joachimgoedhart
Joachim Goedhart
2 years
"Here, we successfully use LIVE-PAINT to image yeast membrane proteins that do not tolerate the direct fusion of a fluorescent protein by using peptide tags as short as 5-residues".
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@ShawnShortill
Shawn Shortill
2 years
RT @hannes_maib: Finally the community has a reliable, specific and high affinity probe to detect PI(3,5)P2 ! I am very excited about the n….
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@ShawnShortill
Shawn Shortill
2 years
@PerryHo21793268 @uvic @UVicBCMB @Camosun @SuferDrude @pcstirling @HieterLab @UBC @conibear_liz For my next steps, I’ll be joining @pcstirling and @HieterLab to leverage synthetic lethality in DNA repair pathways for the treatment of various cancers. Stay tuned for more! 4/4.
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@ShawnShortill
Shawn Shortill
2 years
@PerryHo21793268 @uvic @UVicBCMB @Camosun @SuferDrude @pcstirling @HieterLab @UBC Most of all, I want to thank @conibear_liz for being such an inspiring mentor and fiercely creative scientific role model. It was a privilege to work in the Conibear lab, and it wouldn’t be possible to synthesize all of the things I learned from Liz into a single tweet. (3/n).
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@ShawnShortill
Shawn Shortill
2 years
I want to briefly thank some very important mentors I’ve had over the years, including Chris Nelson (not on Twitter) and @PerryHo21793268 at @uvic @UVicBCMB, Larry Anthony (not on Twitter at @Camosun, and @SuferDrude, @pcstirling, @HieterLab at @UBC. 2/n.
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@ShawnShortill
Shawn Shortill
2 years
I’m excited to share that after five amazing years with @conibear_liz and @UBC @CMMT_UBC, I have defended my doctoral dissertation and finished my PhD in Medical Genetics. We made some exciting discoveries over the years, and published papers that I’m truly proud of. 1/n.
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@ShawnShortill
Shawn Shortill
2 years
RT @ArrowsmithGx: Arrowsmith Genetics is excited to be in Round 3 of the New Ventures BC competition. Looking forward to meeting our mentor….
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@ShawnShortill
Shawn Shortill
3 years
A good perspective on the new changes @elife from a senior editor:.
@LnccBrown
Franklab_LNCC
3 years
as a long time seniorĀ editor for @eLife I (MJF) thought I'd weigh in. When I first heard about the plan in its initial conception, I had my reservations for many of the same reasons some of you articulating. I've changed my mind. I think it is worth a shot.
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@ShawnShortill
Shawn Shortill
3 years
We have all (rightfully) complained about how flawed the current science publishing system is. The @eLife team is now challenging this status quo by abandoning the traditional ā€œaccepted manuscriptā€ title to instead publish everything that gets reviewed, along with an assessment.
@eLife
eLife - the journal
3 years
Today, we’re introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish.
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@ShawnShortill
Shawn Shortill
3 years
Cool!.
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@ShawnShortill
Shawn Shortill
3 years
Manuscript accepted!! šŸ•ŗšŸ¼šŸ¾ This was a large, multi-lab project and I’m happy to have contributed to its success. Stay tuned for yeast membrane contact sites, lipid biology and a first glimpse at the (very) complicated inner workings of a potential new lipid transport protein—Lec1
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@ShawnShortill
Shawn Shortill
3 years
Normalize bedroom genome assembly and annotation šŸ›ļøšŸ§¬.
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@ShawnShortill
Shawn Shortill
3 years
RT @koborlab: Come work with us - exciting opportunity to get in at the early stage and substantially contribute to shaping the future and….
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@ShawnShortill
Shawn Shortill
3 years
Congratulations @SaketBagde! This is so exciting and well deserved.
@Fromme_Lab
Fromme Lab
3 years
Congratulations to our own @SaketBagde for winning the Spicer Young Investigator award!!!! šŸŽ‰šŸŽ‰šŸŽ‰
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@ShawnShortill
Shawn Shortill
3 years
RT @MEDGGSA: Thank you Cheryl Bishop for all your years of service in Medical Genetics. You will be missed. We wish you a very happy retir….
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@ShawnShortill
Shawn Shortill
3 years
RT @ivancedric_a: Prince Charles updating his email signature like PhD students after passing their candidacy exams.
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@ShawnShortill
Shawn Shortill
3 years
RT @JoePerkinsCHEK: A sneak peek inside Victoria’s former Canoe Club. Officially opens as CRAFT sometime in September. #yyj .
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