
Shawn Shortill
@ShawnShortill
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PhD, Medical Genetics from @UBC @CMMT_UBC 𧬠Investigating synthetic lethality in DNA repair pathways @BCCancer š„ Opinions are mine, RT/like ā endorse
Vancouver, British Columbia
Joined January 2021
Iām very excited to share that my PhD work is now published @eLife! We used a combination of genetics, cell biology and biochemistry to identify a new endosomal complex in yeast, which we named VINE šæ Early access here: (1/n).
elifesciences.org
The yeast VARP homolog forms a new sorting nexin complex that promotes its own membrane recruitment through GEF activity and regulates the distribution of endosomal proteins.
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RT @DdelAlamo: "Reliable protein-protein docking with AlphaFold, Rosetta and replica-exchange". Some promising results on antibody-antigenā¦.
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Interesting paper, awesome name for a shortened BAR domain!.
MiniBAR has a unique truncated BAR domain, is a dual Rac / Rab #GTPases effector and controls both actin cytoskeleton and membrane trafļ¬cking in ciliogenesis. #RabGTPases #RhoGTPases #actin #myosin #membranetraffic #ciliopathies #zebrafish #cilia
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Yeast friendsāthis is an interesting approach to getting around stubborn, tag-intolerant proteins for imaging studies.
"Here, we successfully use LIVE-PAINT to image yeast membrane proteins that do not tolerate the direct fusion of a fluorescent protein by using peptide tags as short as 5-residues".
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RT @hannes_maib: Finally the community has a reliable, specific and high affinity probe to detect PI(3,5)P2 ! I am very excited about the nā¦.
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@PerryHo21793268 @uvic @UVicBCMB @Camosun @SuferDrude @pcstirling @HieterLab @UBC @conibear_liz For my next steps, Iāll be joining @pcstirling and @HieterLab to leverage synthetic lethality in DNA repair pathways for the treatment of various cancers. Stay tuned for more! 4/4.
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@PerryHo21793268 @uvic @UVicBCMB @Camosun @SuferDrude @pcstirling @HieterLab @UBC Most of all, I want to thank @conibear_liz for being such an inspiring mentor and fiercely creative scientific role model. It was a privilege to work in the Conibear lab, and it wouldnāt be possible to synthesize all of the things I learned from Liz into a single tweet. (3/n).
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I want to briefly thank some very important mentors Iāve had over the years, including Chris Nelson (not on Twitter) and @PerryHo21793268 at @uvic @UVicBCMB, Larry Anthony (not on Twitter at @Camosun, and @SuferDrude, @pcstirling, @HieterLab at @UBC. 2/n.
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Iām excited to share that after five amazing years with @conibear_liz and @UBC @CMMT_UBC, I have defended my doctoral dissertation and finished my PhD in Medical Genetics. We made some exciting discoveries over the years, and published papers that Iām truly proud of. 1/n.
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RT @ArrowsmithGx: Arrowsmith Genetics is excited to be in Round 3 of the New Ventures BC competition. Looking forward to meeting our mentorā¦.
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A good perspective on the new changes @elife from a senior editor:.
as a long time seniorĀ editor for @eLife I (MJF) thought I'd weigh in. When I first heard about the plan in its initial conception, I had my reservations for many of the same reasons some of you articulating. I've changed my mind. I think it is worth a shot.
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We have all (rightfully) complained about how flawed the current science publishing system is. The @eLife team is now challenging this status quo by abandoning the traditional āaccepted manuscriptā title to instead publish everything that gets reviewed, along with an assessment.
Today, weāre introducing a new model that eliminates accept/reject decisions. By publishing every paper with eLife reviews as a Reviewed Preprint, we plan to restore autonomy to authors, ensuring that they will be judged by what, not where, they publish.
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RT @koborlab: Come work with us - exciting opportunity to get in at the early stage and substantially contribute to shaping the future andā¦.
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Congratulations @SaketBagde! This is so exciting and well deserved.
Congratulations to our own @SaketBagde for winning the Spicer Young Investigator award!!!! ššš
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RT @MEDGGSA: Thank you Cheryl Bishop for all your years of service in Medical Genetics. You will be missed. We wish you a very happy retirā¦.
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RT @ivancedric_a: Prince Charles updating his email signature like PhD students after passing their candidacy exams.
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RT @JoePerkinsCHEK: A sneak peek inside Victoriaās former Canoe Club. Officially opens as CRAFT sometime in September. #yyj .
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