Thrilled to present our structure of glycine transporter 1 (GlyT1) with @PoulNissen and twitterless Roger Dawson and Thomas Schneider and @seegerlab. @dandrite @MolBiolAU @embl (SSX data collected @P14 beamline operated by @EMBLHAMBURG at PETRA III storage ring @desy).

Join us ! 2.5-year postdoc position in our group in Denmark. Membrane protein simulations and machine learning applications. Ample flexibility in the project to leave your mark on it. Please apply here, I cannot entertain applications on email. https://t.co/8zx9KVy6qZ

We are grateful for the support from: @lundbeckfonden @novonordiskfond @NIDAnews @UCPH_Research

This interdisciplinary research represents nothing less than a tour de force by @rcantwellchater , and a great collaborative effort between the labs of @robertvandenbe2, @ Christopher Cioffi, @ Megan O'mara, @ Mike Michaelides, @ Sarasa Mohammadi and myself.

Our findings provide proof-of-concept for the rational design of GlyT2 inhibitors and a clear avenue for novel treatments of chronic neuropathic pain.

We show that RPI-GLYT2-82 is efficacious at alleviating pain in mouse models of neuropathic pain with no mechanism-based side effects tested at doses up to 5 times the maximal analgesic dose, or addiction liability at up to 3 times the maximal analgesic dose.

We have determined the first #cryoEM structures of human GlyT2 bound to a potent pseudo-irreversible inhibitor (ORG25543) that failed in pre-clinical studies, a novel and reversible inhibitor (RPI-GLYT2-82), and in the substrate-free state.

Beyond excited to present our study on the glycine transporter #GlyT2, a promising #non-opioid target for the treatment of neuropathic pain. @biorxivpreprint https://t.co/klVxUQKhAy

and @Core Facility for Integrated Microscopy – CFIM – funded by @novonordiskfond, where we collected our cryo-EM data on the first batch of newly developed HexAuFoil grids from @quantifoil

Our study will facilitate the structure-based design of improved selective inhibitors targeting GAT3 for more efficient treatment of epilepsy and a range of other neurological disorders. We are grateful for the support from @lundbeckfonden @novonordiskfond @DFF_raad

Our inhibitor-bound inward-open GAT3 reveals the binding mode of SR-THAP and the structural determinants of selectivity. Our GABA-bound inward-occluded GAT3 reveals ion coordination and substrate recognition network with exciting distinction to that previously observed for GAT1 .

We are excited to present the first #cryoEM structures of human GABA transporter 3 – GAT3 – bound to an in-house selective inhibitor, SR-THAP, to substrate GABA, and in the substrate-free state! @biorxivpreprint https://t.co/42BnBDvNE3

Happy #Nowruz! Happy first day of spring! 🌺

What is the meaning of life? Hear 2021 chemistry laureate Benjamin List answer the question we all are trying to find an answer to. #NobelPrize

زندگی یک وطن بهم بدهکاره که توش فقط به زندگی فکر کنم نه به وطن. | #کیانوش_سنجری |

Excited to share our latest research on how cholesterol influences the clustering and plasma membrane curvature biogenesis of the influenza M2 proton channel using coarse-grained MD simulations! 🦠🧬 Read the paper here:

They moved it back, up again 🥲

It’s never too late. Start.

Excited for the #isbuc annual meeting. One more exciting meeting with key leaders in the field discussing cutting edge technologies bridging structural biology with applied biomedicine. @cloland_dk opening the symposium

Gefion, Danmark’s new #AI supercomputer, was launched today. A state-of-the-art #NVIDIADGX SuperPOD with 1528 NVIDIA H100 Tensor Core GPUs, it is ready to accelerate research in #quantum, #healthcare and #greentech. The Novo Nordisk Foundation works with @Eifo_fond and @nvidia

One of the brightest, most beautiful autumns we’ve had in #Copenhagen ⁦@UCPH_Research⁩ 🍂🍁