SemrauLab
@SemrauLab
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The Semrau Lab is interested in quantitative stem cell biology. We use molecular profiling and machine learning to study iPSC-derived disease models.
New York Stem Cell Foundation
Joined September 2015
Congrats to the first authors Martijn de Jong and Esmée Adegeest on a great piece of research and thanks to @roeland_merks for a productive collaboration.
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Using Cellular Potts Model simulations and accurate shape quantification we show that gastruloids are shaped by a combination of active cell crawling and differential adhesion.
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Check out our new publication in PLOS Computational Biology on morphogenesis in gastruloids (.
journals.plos.org
Author summary During embryonic development, a mammalian embryo develops from a single cell to a complete organism with a complex body plan. To ensure that tissues and organs are formed exactly in...
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identify post-transcriptional regulatory mechanisms. Thanks to @slavov_n for a great collaboration!.
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Our multi-omics study of stem cell differentiation dynamics is out in PLOS Genetics (. We show how a dynamical model of gene expression can be used to explain the discordance between mRNA and protein abundance and ….
journals.plos.org
Author summary Pluripotent stem cells, which can be derived from an adult individual, can be grown indefinitely in a dish and turned into each cell type of the body. These abilities enable applicat...
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RT @ItaiYanai: Congratulations to DR. Maria Mircea for defending her PhD thesis today! It was a true honor to serve on her committee and I'….
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Thank you @Siliegia for being an amazing PhD student! It was a pleasure to be your supervisor.
Received my PhD today! Many thanks to my supervisor @SemrauLab. Thanks to @ItaiYanai for being part of my committee. And also thanks to my paranymphs @JuliaEckert10 and @GeorgeDadu_!
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Happy to share that our study of co-differentiation of cardiomyocytes and endothelial cells from human iPSCs was published in Stem Cells Excellent work by @Xu_Cao_PhD and @Siliegia and a great collaboration with the Orlova lab.
academic.oup.com
Abstract. The ability to differentiate human-induced pluripotent stem cells (hiPSCs) efficiently into defined cardiac lineages, such as cardiomyocytes and
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developmental biology, bioinformatics, deep learning and systems biology, join us! We have an opening for a postdoctoral fellow in computational biology Please share with anybody who might be interested!.
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Big news: The Semrau lab has moved to @nyscf, the New York Stem Cell Foundation! We are excited to help realize the amazing medical potential of stem cells and look forward to collaborations with many excellent colleagues. If you like our research at the intersection of.
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RT @NCBStheory: After 4 days of exciting talks, posters, discussions and lots of fun, #CLD2022 finally came to an end today!. A very big th….
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Enjoying great discussions at #CLD2022 in beautiful Alleppey.
The next two sessions for Day 2 of #CLD2022 included some excellent talks by:. - @ArjunGuha1.- @semrau_stefan.- @shaon_chak.- #PhilippThomas. On a variety of topics ranging from cellular #lineages, #differentiation, plasticity, single cell molecules & stochastic #gene expression!
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Here's my answer: I hope you will find it interesting. Thanks a lot @arjunrajlab for getting me to think about this! I am also really grateful for encouragement and feedback from @ItaiYanai, @LaanLiedewij and Günter P. Wagner. 2/2.
frontiersin.org
Since the discovery of cells by Robert Hooke and Antoni van Leeuwenhoek in the 17th century, thousands of different cell types have been identified, most rec...
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A while ago @arjunrajlab asked: What are open conceptual questions in the single-cell field? My suggestion: How can we explain the scaling relationship between the number of cell types and the number of cells in an organism? 1/2.
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RT @ItaiYanai: New Night Science paper! "What puzzle are you in?" Doing science is like solving puzzles; of which we propose there are 4 Cl….
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RT @ItaiYanai: Thrilled to announce the 2022 Night Science 1 day workshop! Join us in Amsterdam August 9th to learn & practice the creative….
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RT @ItaiYanai: Ever hear that ‘necessity is the mother of invention’? In our new work, we found that it’s also true for cancer cells as the….
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Thrilled to announce that our paper on XEN-enhanced gastruloids is now online . We hope you'll find it interesting. Thanks to everybody involved for all of the hard work!.
journals.sagepub.com
Stem-cell derived in vitro systems, such as organoids or embryoids, hold great potential for modeling in vivo development. Full control over their initial compo...
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RT @Siliegia: Our new paper from @SemrauLab on clusterability of scRNA-seq data is now published in Genome Biology! The new name is phiclus….
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