Pabi Sahoo (ପବିତ୍ର ସାହୁ)
@SahooLab
Followers
421
Following
1K
Media
37
Statuses
512
Assistant Professor at Rutgers University | Molecular Neurobiologist | Neural repair | Neurodevelopment
Newark, NJ
Joined June 2018
Our CNS regeneration work is now online. Terrific postdocs @manasiagrawal1 and @meghaldesai completed the revision experiments. @RutgersSASN @RutgersU
https://t.co/eBTWbMhd9G
pnas.org
Depletion or inhibition of core stress granule proteins, G3BP1 in mammals and TIAR-2 in Caenorhabditis elegans, increases the growth of spontaneous...
3
6
22
Super cool results from the @jltwiss1 lab. Source: bioRxiv
biorxiv.org
Injured axons synthesize the RNA Binding Protein KHSRP that promotes mRNA decay and slows nerve regeneration. Axotomy-induced increase in axoplasmic Ca2+ activates axonal Khsrp translation, and while...
0
2
4
Read this excellent story from the @jltwiss1 lab. Acetylation of Axonal G3BP1 through ELP3 Accelerates Axon Regeneration
biorxiv.org
Nerve injury triggers localized translation of axonal mRNAs to respond to injury and nerve regeneration. The core stress granule protein G3BP1 sequesters axonal mRNAs in granules before and after...
0
6
12
Thrilled to share our new work in Nature Neuroscience! Together with amazing collaborators and led by Ariel Ionescu, we discovered that muscle-derived miR-126 controls local axonal TDP-43 synthesis and protects neuromuscular junctions in ALS. https://t.co/FMksQim7eF
nature.com
Nature Neuroscience - Ionescu, Ankol et al. show that, in ALS mouse and iPSC models, TDP-43 aggregation at NMJs stems from aberrant axonal translation, normally repressed by muscle EV-derived...
4
4
26
Meghal and Shruti received the BHI travel award. Congratulations both! https://t.co/tHnl2fxcCc
brainhealthinstitute.rutgers.edu
0
0
3
Super cool results from the Vande Velde lab. TDP-43 pathology triggers SRRM4-dependent cryptic splicing of G3BP1 in ALS/FTD
biorxiv.org
Loss of nuclear TDP-43 is a defining feature of the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), yet how this leads to selective neuronal vulner...
0
0
0
It was fun presenting our work at the @ISN-ASN conference last week. @manasiagrawal1 @meghal @GhumraShru98494
0
1
6
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch | Science
science.org
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell...
1
10
44
Proud mentor moment as Shruti passes her Ph.D. qualifiers 🎉 Congratulations, Shruti!
1
2
16
Stathmin-2 enhances motor axon regeneration after injury independent of its binding to tubulin | PNAS
pnas.org
Stathmin-2 (also known as SCG10) is encoded by the STMN2 gene, whose mRNA is one of the most abundantly expressed in human motor neurons. In almost...
0
0
2
Very exciting results from the Fainzilber lab. Happy to be a part of this story! Repeat-element RNAs integrate a neuronal growth circuit: Cell
cell.com
SINEs of recovery: A subset of small RNAs encoded by repetitive genomic elements are induced by nerve lesion to regulate protein synthesis and enhance axonal growth.
0
1
5
Thanks to Laurent and all the other authors. The end of a long journey to publication. https://t.co/FMnEbwlblt
science.org
The protective role of ATP in neurons reduces protein aggregation and neurodegeneration.
1
7
23
Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution: Cell
cell.com
An immune cell population found in humans and a number of large vertebrates resembles microglia of the central nervous system in terms of transcriptome, epigenome, protein markers, and ontogeny but...
0
0
1
Excellent story from the Woolf lab! Non-muscle myosin II inhibition at the site of axon injury increases axon regeneration | Nature Communications
nature.com
Nature Communications - Therapeutic interventions for motor axon regeneration following peripheral nerve injury are currently unavailable. Here authors show local administration of a non-muscle...
0
0
1
0
0
1
It was a huge undertaking in collaboration with @jltwiss1 @Larrybenowitz @WardLab_Emory @KristyWelshhans @Marktuszynski @jenniferDulin @ArthurEnglish @JohnHolule labs. Thank you all and @MerkinPnnrCtr for funding 🙏
1
2
5
0
0
0
Big shout out to @meghal_desai @keyagulati @manasiagrawal1 @shrutighumra. Thanks @MerkinPnnrCtr for funding 🙏🏼
1
0
2
First peer reviewed article from our lab is now out. If you are new to stress granule field, you will find this manuscript helpful. @NRRNeural Stress granules: guardians of cellular health and triggers... : Neural Regeneration Research
journals.lww.com
play a critical role in minimizing cellular damage during stress. Composed of heterogeneous ribonucleoprotein complexes, stress granules are enriched not only in mRNAs but also in noncoding RNAs and...
3
3
13