SickKids Developmental & Stem Cell Biology Program
@SKDevStemCell
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Understanding the molecular and genetic mechanisms of a variety of developmental disorders and paediatric diseases to improve global child health outcomes.
Toronto, Canada
Joined February 2021
RT @BrainSurgn1989: Very pleased to post this new study from my group led by Kinjal Desai, targeting a rare cell fate OLIG2-mediated transi….
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RT @augusto_zani: Great job @FabianDoktor and the @Zani_Lab! Another important paper highlighting the effects of #EVs on fetal hypoplastic….
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RT @matt_eroglu: Why are so many inherited traits not explained by genome sequence variation? In my PhD work with @wbderry we describe a ne….
nature.com
Nature Cell Biology - Eroglu et al. describe protein amyloid structures that are stably inherited across generations and transmit epigenetic memory in Caenorhabditis elegans. MSTR protein...
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Ulcers increase the risk of gastric cancer, but the mechanisms underlying this association remain unclear. The Kim and Guo labs demonstrate that YAP signaling promotes both gastric regeneration and metaplasia, a precancerous lesion.
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RT @SickKidsNews: A newly discovered protein-protein interaction has sparked the development of a novel treatment for #glioblastoma 🧠. Publ….
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RT @XiHuang18: Today, we report in @NatureCancer a new approach to treat glioblastoma (GBM). First and foremost, this is the work of recent….
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Great work!! Congratulations!.
Excited to share our paper "Mechanical nanosurgery of chemoresistant glioblastoma using magnetically controlled carbon nanotubes" led by our extremely talented postdoctoral fellow Xian Wang.
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Kim and Wilson labs at SickKids have defined the epigenetic regulation of mesenchymal niche signals in stomach and intestinal development.
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RT @NeuroCellPress: First 2023 issue is out! Cover art by Siqi Ou illustrates Chen & coll. findings on mechanosensi….
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Dr. Tae-Hee Kim's lab identifies key immune and microbial factors in the gut that influence newborn stem cell development, with implications for the treatment of necrotizing enterocolitis.
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Congratulations Dr. Vijay Ramaswamy @vijayvijay1979 for Canada Research Chair award (Tier II) to identify weaknesses in medulloblastoma and ependymoma, the first and third most common paediatric brain cancers. @SKDevStemCell @SickKidsCancer @sickkids
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lab.research.sickkids.ca
A SickKids team led by Dr. Xi Huang has uncovered the mechanics of the blood-tumour barrier, laying the foundation for more effectively treating medulloblastoma, the most common malignant paediatric brain tumour. Read more ➡️ #SKResearch
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Congratulations Maria!.
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Congratulations!!.
🥳YAYY!!🥳Incredibly happy to share our work on the Human origins of Group 4 Medulloblastoma published today in @Nature. Massive collaborative effort to nail down a cell type found only in developing human brains as the cell of origin of these tumors.
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Congratulations to Dr. Tae-Hee Kim @SKDevStemCell for securing the @CIHR_IRSC operating grant titled: Mechanisms of intercellular communications in gut homeostasis and disease. @SickKidsNews @sickkids @CIHR_ICR
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RT @BrainTumourFdn: Dr. Xian Wang is one of our Brain Tumour Research Fellowship recipient. We are so grateful for is amazing work and how….
braintumour.ca
Xian Wang Postdoctoral Research Fellow at the Hospital for Sick Children, Toronto, ON Project Entitled: “Targeted mechanical ablation of Glioblastoma […]
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Using this approach, they have discovered mechanical force-activated calcium dynamics at nanoscale resolution within single brain tumour cells. @SKDevStemCell @SickKidsNews @CIHR_ICR @BrainTumourFdn @acsnano @SRC_CRS @theABTA @sickkids @SickKidsCancer.
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They have developed a magnetic robotic system to control fluorescent dye-coated nanoparticles to form a swarm for intracellular ionic measurement. Their system displays a signal-to-noise ratio ten times higher than traditional ionic dyes.
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