Greg Roloff
@RoloffGreg
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Academic hematologist interested in leukemia, cell/gene therapy, transplant. Buffalo born. Views, typos, and grammatical errors = mine
Chicago, IL
Joined June 2020
Topline results studying brexu-cel in relapsed B-ALL, now out @JCO_ASCO. My thanks to @LoriMuffly and partners from 30+ centers driven to answer ?s in a rare disease space. More to come. @bshah @MoffittNews @UChicagoHemOnc .
ascopubs.org
PURPOSEOn the basis of the results of the ZUMA-3 trial, brexucabtagene autoleucel (brexu-cel), a CD19-directed chimeric antigen receptor T-cell therapy, gained US Food and Drug Administration...
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RT @drclaireroddie: Thanks again @RoloffGreg for fantastic & thought provoking commentary piece. Still so much to learn about tMN post-CAR…….
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RT @ARampotas: Thrilled to share our latest study on secondary myeloid malignancies after CAR-T cell therapy led by Dr Francesca Sillito .@….
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RT @CARTTherapy: Matched donor allogeneic CAR-T for adult B-ALL: toxicity, efficacy, repeat dosing, and the importance of lymphodepletion h….
ashpublications.org
Key Points. Matched allogeneic donor CD19CAR-T (CAR-DLI) is safe and effective for relapsed adult B-ALL but only following pre-CAR-T lymphodepletion.Repeat
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RT @MediHumdani: Our deeper dive on @BMTCTN 1506 aka Morpho trial: FLT3-ITD/NPM1 co mutants with residual MRD uniquely benefit from #gilter….
ashpublications.org
Key Points. Myeloablative conditioning was no more effective than reduced intensity conditioning in eradicating FLT3-ITD measurable residual disease.NPM1 c
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RT @OncLive: We are honored to congratulate @DrWendyStock of @UCCancerCenter for her 2025 Giants of Cancer Care Leukemia induction! #Giants….
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Obecabtagene Autoleucel Emerges as an Avenue for Adults With Relapsed/Refractory B-Cell Acute Lymphoblastic Leukemia
ashpublications.org
Roddie C, Sandhu KS, Tholouli E, . Obecabtagene autoleucel in adults with B-cell acute lymphoblastic leukemia. N Engl J Med. 2024;391(23):2219-2230. PubMed
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RT @UChicagoHemOnc: More great research coming from our @UCHemOncFellows!! Drs. Shaw, Cannova, Johnston, and Madero-Marroquin in @BloodAdva….
ashpublications.org
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RT @UCCancerCenter: WATCH: @DanielOlsonMD discusses the potential of TIL therapy, a groundbreaking cancer treatment that transformed cancer….
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RT @susanamendoza10: Excellent OpEd by @AldConway @NewDayConway on need to end the fiscal recklessness on full, daily display in Chicago by….
chicagotribune.com
The size and the schedule for an additional $830 million in debt are reckless and could be more responsibly structured by Mayor Brandon Johnson.
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RT @UChicagoHemOnc: Congratulations to our Section Chief, Dr. @SoniSmithMD new electee to the @ASCO Board of Directors as the Designated Me….
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RT @UChiPritzker: For the seventh time, University of Chicago Medical Center has been named a Top Teaching Hospital by the @LeapfrogGroup f….
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New annual tradition at ASH 🩸 💪
Another @ASH_hematology #ASH24 highlight: making new friends from around the world while lifting heavy weights with @DrHelenOram and @RoloffGreg . Shoutout to @mjbrunns and @sghmd for starting this tradition! Missed y’all!
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Is there any pumping of iron happening at ASH this year @sghmd @rmistry91 ? If so I want in 💪.
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RT @OncLive: Obe-Cel Approval Expands CAR T-Cell Therapy Options in Relapsed/Refractory ALL.@LoriMuffly @StanfordMed @MDAndersonNews @Rolof….
onclive.com
Hematologic oncologists offer their perspective on the current and potential future standing of CAR T-cell therapies in the relapsed/refractory ALL treatment landscape.
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RT @bshah: Obecabtagene Autoleucel in Adults with B-Cell Acute Lymphoblastic Leukemia | New England Journal of Medicine .
nejm.org
Obecabtagene autoleucel (obe-cel) is an autologous 41BB-ζ anti-CD19 chimeric antigen receptor (CAR) T-cell therapy which uses an intermediate-affinity CAR to reduce toxic effects and improve persis...
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RT @Haematologica: How can we expedite the evaluation of hereditary hematopoietic malignancies in the setting of stem cell transplantation….
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RT @edels0n: Every societal ill, every political absurdity, every economic issue in America. Can be explained by this chart .
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RT @Anand_88_Patel: Thrilled to share a @Haematologica review I wrote w/ the mentorship of @RaajitRampal! We tackle MPN-AP/BP in a few ways….
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